Michigan State University

Matthew Neiditch

Martin F Semmelhack

Christopher Waters

Karthik Sambanthamoorthy

The various embodiments relate to a compound comprising: wherein R, R, R, R, R, R, R, R, R, R, R, and Rare each independently hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclyl, alkoxy, aryloxy, heteroaryloxy, alkoxycarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, alkylsulfonyl, arylsulfonyl, aminosulfonyl, alkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, acyl, acylamino, amino, alkylamino, dialkylamino, arylamino, carboxylate (&#x2014;COH), cyano, nitro, &#x2014;CONH2, heteroarylamino, oxime, alkyloxime, aryloxime, amino-oxime or halogen when A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, and Q are carbon, and X is O, NR (where R is hydrogen, alkyl, aryl or acyl), S, SO (sulfoxide), SO(sulfone), or C(R)(where R=H, alkyl, aryl, alkenyl, alkynyl, or acyl); or wherein R, R, R, R, R, R, R, R, R, R, R, and Rare each independently hydrogen or hydroxyl when A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, and Q are each independently nitrogen, and compositions, combinations, pharmaceutically acceptable salts, esters, and prodrugs thereof. The invention also relates to methods of using such compounds and compositions.

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Princeton Junction, NJ, United States of America

Matthew Neiditch