Pfizer Corporation

Other

Sleep Technologies, LLC

Pfizer Products Inc.

Matthew Merrill Hayward

Patrick Robert Verhoest

Matthew Frank Brown

Thomas Allen Chappie

Nandini Chaturbhai Patel

Christopher John Helal

Travis T Wager

Erik Alphie LaChapelle

Simone Sciabola

Li Huang Xing

Dafydd Rhys Owen

Stephen Wayne Wright

Brian Stephen Gerstenberger

Andrew Fensome

Michael Luzzio

Mark Edward Flanagan

Adam Matthew Gilbert

Atli Thorarensen

Rayomand Jal Unwalla

John Isidro Trujillo

Ye Che

Samit Kumar Bhattacharya

Joseph Michael Young

Kevin Daniel Freeman-Cook

Xiaojing Yang

Agustin Casimiro-Garcia

Jean-Baptiste Telliez

Jun Xiao

Christopher Lowell Autry

Kendra Louise Nelson

Alpay Dermenci

Xumiao Zhao

Catherine Angela Hulford

Lei Zhang

Jotham Wadsworth Coe

Mark William Foohey

Jaclyn Louise Henderson

Justin Ian Montgomery

Heather Benoit

Bethany Lyn Kormos

Antonia Friederike Stepan

Paul Galatsis

Robert Barron Duncan

Jonathan David Langille

Ravi G Kurumbail

J Kevin Gentry

Erik Alphie Lachapelle

Takushi Kaneko

Robert G Linde, Ii

John I Trujillo

Laura Cook Blumberg

Amy Beth Dounay

Katherine E Brighty

Jamison Bryce Tuttle

Sidney Xi Liang

Andrei Shavnya

Felix Vajdos

Christopher Stanley Poss

Michelle Marie Claffey

Suobao Rong

Samuel C Scudder

Xinmin Gan

Gregory D Lundquist

Michael S Visser

Andre Shavnya

Gregory Dean Lundquist

Travis T Wagner

A compound having the structure: or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or pharmaceutically acceptable salt, wherein A, A' and A″ are independently O, C═O, C—R′ or N—R″, where R′ and R″ may independently be H, amino, —NRCOR, COR, —CONRR, C-Calkyl, or hydroxy(C-Calkyl), and R″ may be present or absent, and is present where the rules of valency permit, and where not more than one of A, A′ and A″ is O or C═O; Rand R are independently H, Br, Cl, F, or C-Calkyl; Ris H, C-Calkyl, or hydroxy(C-Calkyl); Ris selected from the group consisting of H, C-Calkyl, C-Calkoxy, hydroxy(C-Calkyl), phenyl(C-Calkyl), formyl, heteroaryl, heterocyclic, —COR, —OCOR, —COOR, —NRCOR, —CONRR, and —(CH)—W, where W is cyano, hydroxy, C-Ccycloalkyl, —SONRR, and —SO—R, where Ris C-Calkyl, C-Ccycloalkyl, heteroaryl, or heterocyclic; wherein each of said alkyl, cycloalkyl, heterocyclic, or heteroaryl may be unsubstituted or substituted by halo, cyano, hydroxy, or C-Calkyl; X is C—Ror N, where Rmay be H or C-Calkyl; Rand Rare independently H, amino, C-Calkyl, or hydroxy(C-Calkyl); R, Rand Rare each independently H, C-Calkyl, C-Calkoxy(C-Calkyl), or C-Ccycloalkyl, said C-Calkyl is optionally substituted by halo, CN or hydroxy; or, Rand Rtogether with the atom bonded thereto form a 5- or 6-membered ring, said ring being optionally substituted by halo, hydroxy, CN, or C-Calkyl; and, n is 0, 1, 2 or 3. Also provided are methods of treatment as Janus Kinase inhibitors and pharmaceutical compositions containing the compounds of the invention and combinations thereof with other therapeutic agents.

Pyrazolo[1,5-a]pyrazin-4-yl derivatives

An adjustable sleeping system. At least some of the example embodiments are an adjustable sleeping system comprising a plurality of spring modules arranged in a first column, each spring module defines a row within the first column. Each spring module may comprise a rail and a plurality of adjustable spring assembles coupled along the rail. Each adjustable spring assembly may comprise a motor coupled to the rail, a lead screw coupled to a rotor of the motor, a spring plate coupled to the lead screw, and a spring coupled to the spring plate. A bed controller is communicatively coupled to each spring module, and the bed controller is configured to selectively control a load carried by each spring assembly.

Methods and systems of an adjustable sleeping system

The present invention provides a method for treating alopecia using certain pharmaceutically active pyrrolo[2,3-d]pyrimidinyl acrylamides having the structure: or a pharmaceutically acceptable salt thereof, as set forth in the Description.

Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl and pyrrolo[2,3-d]pyridinyl acrylamides

Spring modules for an adjustable sleeping system. At least some of the example embodiments are spring modules comprising: a spring rail, and a plurality of adjustable spring assemblies spaced along the length of the spring rail. Each adjustable spring assembly may comprise: a motor with a stator coupled to the spring rail, a lead screw coupled to the rotor of the motor, and the lead screw extending above an upper surface of the spring rail, a spring plate coupled to the lead screw, and a main spring coupled to the spring plate. Thus, the weight or force carried by each adjustable spring assembly along the spring rail is separately adjustable by a bed controller.

Methods and systems of spring modules for an adjustable sleeping system

There is a method for treating a psoriasis. A compound is administered in a therapeutically effective amount to a subject suffering therefrom. The compound has the structure or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof.

Adjustable sleeping system with massage function. At least one example embodiment is a method of operating a sleeping system, the method including massaging a person residing on a sleeping surface of the sleeping system, the massaging by driving a plurality of adjustable spring assemblies, the plurality of adjustable spring assemblies part of an array of adjustable spring assemblies arranged such that a top of each adjustable spring assembly defines an upper surface parallel to the sleeping surface.

Adjustable sleeping system with massage function

A compound having the structure: or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or pharmaceutically acceptable salt, wherein variables are defined in the specification. Also provided are methods of treatment as Janus Kinase inhibitors and pharmaceutical compositions containing the compounds of the invention and combinations thereof with other therapeutic agents.

Pyrazolo[1,5-A]pyrazin-4-yl and related derivatives

The present invention provides pharmaceutically active pyrrolo[2,3-d]pyrimidinyl and pyrrolo[2,3-d]pyridinyl acrylam ides and analogues thereof, having the structure: or a pharmaceutically acceptable salt thereof, as set forth in the Description. Such compounds are useful for inhibiting Janus Kinase (JAK). This invention also is directed to compositions comprising methods for making such compounds, and methods for treating and preventing conditions mediated by JAK.

A compound compound having the structure: or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or pharmaceutically acceptable salt, wherein A, A' and A&#x2033; are independently O, C&#x2550;O, C&#x2014;R&#x2032; or N&#x2014;R&#x2033;, where R&#x2032; and R&#x2033; may independently be H, amino, &#x2014;NRCOR, COR, &#x2014;CONRR, C-Calkyl, or hydroxy(C-Calkyl), and R&#x2033; may be present or absent, and is present where the rules of valency permit, and where not more than one of A, A&#x2032; and A&#x2033; is O or C&#x2550;O; Rand R are independently H, Br, Cl, F, or C-Calkyl; Ris H, C-Calkyl, or hydroxy(C-Calkyl); Ris selected from the group consisting of H, C-Calkyl, C-Calkoxy, hydroxy(C-Calkyl), phenyl(C-Calkyl), formyl, heteroaryl, heterocyclic, &#x2014;COR, &#x2014;OCOR, &#x2014;COOR, &#x2014;NRCOR, &#x2014;CONRR, and &#x2014;(CH)&#x2014;W, where W is cyano, hydroxy, C-Ccycloalkyl, &#x2014;SONRR, and &#x2014;SO&#x2014;R, where Ris C-Calkyl, C-Ccycloalkyl, heteroaryl, or heterocyclic; wherein each of said alkyl, cycloalkyl, heterocyclic, or heteroaryl may be unsubstituted or substituted by halo, cyano, hydroxy, or C-Calkyl; X is C&#x2014;Ror N, where Rmay be H or C-Calkyl; Rand Rare independently H, amino, C-Calkyl, or hydroxy(C-Calkyl); R, Rand Rare each independently H, C-Calkyl, C-Calkoxy(C-Calkyl), or C-Ccycloalkyl, said C-Calkyl is optionally substituted by halo, CN or hydroxy; or, Rand Rtogether with the atom bonded thereto form a 5- or 6-membered ring, said ring being optionally substituted by halo, hydroxy, CN, or C-Calkyl; and, n is 0, 1, 2 or 3. Also provided are methods of treatment as Janus Kinase inhibitors and pharmaceutical compositions containing the compounds of the invention and combinations thereof with other therapeutic agents.

The present invention is directed to PDE4B inhibitors of Formula I: (I) or a pharmaceutically acceptable salt thereof, wherein the substituents R, R, R, and Rare as defined herein. The invention is also directed to pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, and methods of preparing the compounds. 

6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds

The present invention provides pharmaceutically active pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl, and pyrrolo[2,3-b]pyridinyl acrylamides, epoxides, and analogues thereof. Such compounds are useful for inhibiting Janus Kinase (JAK). This invention also is directed to compositions comprising methods for making such compounds, and methods for treating and preventing conditions mediated by JAK.

Pyrrolo[2,3-D]pyrimidinyl, pyrrolo[2,3-B]pyrazinyl, pyrrolo[2,3-B]pyridinyl acrylamides and epoxides thereof

The present invention is directed to compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein the substituents R, R, R, R, and b are as defined herein. The invention is also directed to pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, and methods of preparing the compounds.

Imidazopyridazine compounds

The present invention relates to a compound of the formula I wherein Rto R, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

Sulfonyl amide derivatives for the treatment of abnormal cell growth

The present invention is directed to compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein the substituents R, R, R, and Rare as defined herein. The invention is also directed to pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, and methods of preparing the compounds.

A compound having the structure: or a pharmaceutically acceptable salt thereof, wherein A, A' and A&#x2033; are independently O, C&#x2550;O, etc.; Rand R are independently H, Br, Cl, F, or C-Calkyl; Ris H, C-Calkyl, or hydroxy(C-Calkyl); Ris selected from the group consisting of H, C-Calkyl, C-Calkoxy, etc.; R, Rand Rare each independently H, C-Calkyl, C-Calkoxy(C-Calkyl), etc.; and, n is 0, 1, 2 or 3. Also provided are methods of treatment as Janus Kinase inhibitors and pharmaceutical compositions containing the compounds of the invention and combinations thereof with other therapeutic agents.

Pyrazolo[1,5-A]PYRAZIN-4-YL derivatives

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Old Lyme, CT, United States of America

Matthew Merrill Hayward