Caribou Biosciences, Inc.

Locanabio, Inc.

Matthew Merrill Carter

Paul Daniel Donohoue

Jennifer A Doudna

Andrew Paul May

Rachel E Haurwitz

James M Berger

Paul Donohoue

A new CRISPR-associated (Cas) protein, termed 'CasM,' is described, as well as polynucleotides encoding the same and methods of using CasM for site-specific genome engineering. CasM proteins are capable of targeting and cleaving single-stranded RNA.

CRISPR-associated (Cas) protein

This disclosure provides for compositions and methods for the use of nucleic acid-targeting nucleic acids and complexes thereof.

Compositions and methods of nucleic acid-targeting nucleic acids

CRISPR-associated (CAS) protein

Compostions and methods of nucleic acid-targeting nucleic acids

This disclosure provides for compositions and methods for the use of nucleic acid-targeting nucleic acids and complexes thereof. Genome engineering can refer to altering the genome by deleting, inserting, mutating, or substituting specific nucleic acid sequences. The altering can be gene or location specific. Genome engineering can use nucleases to cut a nucleic acid thereby generating a site for the alteration. Engineering of non-genomic nucleic acid is also contemplated.

Growing community of inventors

Berkeley, CA, United States of America

Matthew Merrill Carter