Paradigm Genetics, Inc.

Icoria, Inc.

Monsanto Technology LLC

Matthew M Tanzer

Todd DeZwaan

Jeffrey R Shuster

Lisbeth Hamer

Kiichi Adachi

Sanjoy Mahanty

Sze-Chung Lo

Sheryl Frank

Blaise Darveaux

Ryan Heiniger

Amy Skalchunes

Huaqin Pan

Rex Tarpey

Maria Victoria Montenegro-Chamorro

Paul S Chomet

Hongwu Jia

Barry S Goldman

Balasulojini Karunanandaa

Linda L Lutfiyya

Tyamagondlu V Venkatesh

Mark Scott Abad

Donald E Nelson

Huai Wang

Stephen M Duff

Monnanda Somaiah Rajani

Steven H Schwartz

Sasha Preuss

Erin Bell

Dhanalakshmi Ramachandra

Xiaoyun Wu

Zoe P McKiness

Savitha Madappa

Saritha V Kuriakose

Aniruddha Raychaudhuri

Daniel P Schachtman

Char Shobha

Lloyd Jones

Rex Tarper

Maria Victoria Montenegro-Chamarro

This disclosure provides recombinant DNA constructs and transgenic plants having enhanced traits such as increased yield, increased nitrogen use efficiency and enhanced drought tolerance; propagules, progeny and field crops of such transgenic plants; and methods of making and using such transgenic plants. This disclosure also provides methods of producing seed from such transgenic plants, growing such seed and selecting progeny plants with enhanced traits. Also disclosed are transgenic plants with altered phenotypes which are useful for screening and selecting transgenic events for the desired enhanced trait.

Transgenic plants with enhanced traits

The present inventors have discovered that Asparagine Synthase is essential for fungal pathogenicity. Specifically, the inhibition of Asparagine Synthase gene expression in fungi results in no signs of successful infection or lesions. Thus, Asparagine Synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit Asparagine Synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.

Methods for the identification of inhibitors of asparagine synthase as antibiotics

The present inventors have discovered that Threonine synthase is essential for fungal pathogenicity. Specifically, the inhibition of Threonine synthase gene expression in fungi results in no signs of successful infection or lesions. Thus, Threonine synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit Threonine synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.

Methods for the identification of inhibitors of threonine synthase as antibiotics

The present inventors have discovered that histidinol-phosphatase is essential for fungal pathogenicity. Specifically, the inhibition of histidinol-phosphatase gene expression in fungi results in small, non-sporulating lesions and reduced pathogenicity. Thus, histidinol-phosphatase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit histidinol-phosphatase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.

Methods for the identification of inhibitors of histidinol-phosphate as antibiotics

The present inventors have discovered that 3-Isopropylmalate dehydratase is essential for fungal pathogenicity. Specifically, the inhibition of 3-Isopropylmalate dehydratase gene expression in fungi results in no signs of successful infection or lesions. Thus, 3-Isopropylmalate dehydratase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit 3-Isopropylmalate dehydratase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.

Methods for the identification of inhibitors of 3-isopropylmalate dehydratase as antibiotics

The present inventors have discovered that &agr;-Aminoadipate Reductase is essential for fungal pathogenicity. Specifically, the inhibition of &agr;-Aminoadipate Reductase gene expression in fungi results in no signs of successful infection or lesions. Thus, &agr;-Aminoadipate Reductase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit &agr;-Aminoadipate Reductase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.

Methods for the identification of inhibitors of &agr;-aminoadipate reductase as antibiotics

The present inventors have discovered that 5-Aminolevulinate synthase is essential for fungal pathogenicity. Specifically, the inhibition of 5-Aminolevulinate synthase gene expression in fungi results in no signs of successful infection or lesions. Thus, 5-Aminolevulinate synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit 5-Aminolevulinate synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.

Methods for the identification of inhibitors of 5-aminolevulinate synthase as antibiotics

The present inventors have discovered that homocitrate synthase is essential for fungal pathogenicity. Specifically, the inhibition of homocitrate synthase gene expression in fungi results in no signs of successful infection or lesions. Thus, homocitrate synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit homocitrate synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.

Methods for the identification of inhibitors of homocitrate synthase as antibiotics

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Durham, NC, United States of America

Matthew M Tanzer