Venatorx Pharmaceuticals, Inc.

Recurium IP Holdings, LLC

Matthew M Bio

Yuanqing Fang

Daniel McGarry

Franz Amann

Jonas Bürgler

David Ford

Kevin Duane Bunker

Joseph Robert Pinchman

Christopher Breen

Jillian W Sheeran

Andrew M Clausen

Hui Li

Described herein are boron-containing compounds, compositions, and methods for their preparation.

Boron-containing compounds

Processes for making bicyclic compounds and precursors thereof, and particularly for making [1.1.1]propellane and bicyclo[1.1.1]pentane and derivatives thereof, utilize continuous flow reaction methods and conditions. A continuous process for making [1.1.1]propellane can be conducted under reaction conditions that advantageously minimize clogging of a continuous flow reactor. A continuous flow process can be used to make precursors of [1.1.1]propellane.

Continuous flow processes for making bicyclic compounds

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Cambridge, MA, United States of America

Matthew M Bio