Wisconsin Alumni Research Foundation

Matthew Lee Tingey

Nicholas Lawrence Abbott

Yan-Yeung Luk

Brian H Clare

Chang-Hyun Jang

The present invention provides methods, devices and kits for detecting a ligand. The methods involve capturing a ligand from a sample with an affinity substrate that includes a receptor for a ligand, transferring captured ligand to a detection surface and detecting the ligand on the detection surface with a liquid crystal. Accordingly, the capture step is decoupled from the detection step.

Using liquid crystals to detect affinity microcontact printed biomolecules

A method for preparing a metallized surface that possesses gradients in surface topography includes obliquely depositing a metal from a metal source onto a surface of a support. The surface of the support includes a first end, a second end, and a region between the first and second ends. The second end of the surface is located nearer to the metal source than is the first end, and the metal is deposited onto the first end of the surface at a first angle of incidence and the metal is deposited onto the second end of the surface at a second angle of incidence. The first angle of incidence is greater than the second angle of incidence, and the metal is deposited onto the region between the first and second ends at angles of incidence that vary over the region to produce the metallized surface with gradients in surface topography. The angles of incidence are measured from the normal of the support.

Growing community of inventors

Madison, WI, United States of America

Matthew Lee Tingey