Genentech, Inc.

Matthew Lawrence Albert

Yvonne M Chen

Jane Louise Grogan

Zia Khan

Simon-Peter Williams

Eugene Yu-Chuan Chiang

G Scott Chandler

Provided herein are diagnostic and therapeutic methods for the treatment of cancer using polygenic risk scores (PRSs) for dermatological autoimmune diseases. In particular, the invention provides methods for patient selection and methods of treatment.

Diagnostic and therapeutic methods for cancer

Provided are anti-CD8 antibodies that bind human CD8 and do not stimulate or inhibit the activation of CD8T cells. Also provided are nucleic acids encoding such anti-CD8 antibodies, vectors comprising such nucleic acids, host cells comprising same, and methods of making such anti-CD8 antibodies. Also provided are anti-CD8 antibodies conjugated to a detectable label. Provided are methods of using such anti-CD8 antibodies to detect CD8T cells in a subject, monitor disease progress in a subject having cancer, and monitor treatment progress in a subject having cancer.

Anti-CD8 antibodies and uses thereof

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San Francisco, CA, United States of America

Matthew Lawrence Albert