The Cleveland Clinic Foundation

Northeast Ohio Medical University

Juventas Therapeutics, Inc.

Summa Health

Matthew Kiedrowski

Marc S Penn

Joseph M Pastore

Margot S Damaser

Rahul Aras

Maritza Mayorga

Charuspong Dissaranan

Howard B Goldman

Arman Askari

Arman T Askari

Disclosed herein are methods of treating an ischemic or inflammatory condition in an organ or tissue of a patient comprising inducing an increase of the level of CAMKK1 in said organ or tissue.

CAMKK1 as a novel regenerative therapeutic

One aspect of the present disclosure can include a therapeutic composition useful for treatment of a genitourinary disorder. The composition can be derived from a culture media having been in contact with a population of bone marrow-derived mesenchymal stem cells for a sufficient time period necessary to endow therapeutic activity in the culture media. The therapeutic property endowed to the culture media is the ability to promote structural and functional recovery of a dysfunctional organ or biological tissue associated with the genitourinary disorder.

Methods for treating genitourinary disorders

The subject matter provided herein relates to method for inhibiting or mitigating scar formation in a wound of the skin, by increasing the concentration of SDF-1 in, or proximate to, the wound. As described herein SDF-1 protein or an SDF-1 expression vector can be administered to a wound or the area proximate a wound by providing a therapeutically effective amount of SDF-1 protein or an SDF-1 expression vector.

Use of SDF-1 to mitigate scar formation

Chemokines ligands to at least one of CCR1, CCR2, CCR3, or CCR5 can be used to home stem cells for therapeutic applications.

CCR ligands for stem cell homing

Growing community of inventors

Cleveland, OH, United States of America

Matthew Kiedrowski