Gigagen, Inc.

Gigamune, Inc.

Matthew James Spindler

David Scott Johnson

Adam Shultz Adler

Rena Aviva Mizrahi

Yoong Wearn Lim

Ellen Wagner

Michael Asensio

Robert Edgar

Taylor Weller

Ayla Lynn Nelson

The present disclosure relates to a novel, engineered enveloped vector that can be used for gene delivery. The engineered enveloped vector comprises an engineered envelope comprising: (a) a viral envelope protein and optionally, (b) a non-viral membrane-bound protein. The present disclosure also provides a method of making and using the engineered enveloped vector.

Engineered enveloped vectors and methods of use thereof

Provided herein are methods that enable parallel evaluation of multiple functional nucleic acids in individual cells or subpopulations of cells, in the context of incubation with other types of single cells. The key insight is concurrent measurement of polynucleic acids derived from small populations of at least two different cell types, such that function in one cell type is linked to the clonal identity of another cell. These methods simultaneously process thousands, millions, or more single cells or small populations of cells. The method integrates molecular, algorithmic, and engineering approaches. This invention has broad and useful application in a number of biological and medical fields, including immunology and drug discovery.

Systems and methods for massively parallel combinatorial analysis of single cells

Provided herein are compositions comprising recombinant mammalian cells that express recombinant T cell rectors with specificity against EBV or CMV peptide:MHC antigens. Also provided are therapeutic methods of using the recombinant mammalian cells as cell therapies against viral infections.

Engineered cells expressing anti-viral T cell receptors and methods of use thereof

Growing community of inventors

San Francisco, CA, United States of America

Matthew James Spindler