Merck + Co., Inc.

Merck Sharp + Dohme Corp.

University of Washington

Drexel University

Merial Limited

Mmv Medicines for Malaria Venture

Matthew J Wyvratt

Mark T Goulet

Michael H Fisher

William R Schoen

Thomas F Walsh

Lin Chu

Peter J Sinclair

Frederick Wong

William H Parsons

Robert Joseph Devita

Jonathan R Young

Feroze Ujjainwalla

Richard J Bochis

Thomas R Beattie

Peter Lin

Arthur A Patchett

Wallace T Ashton

Mitree M Ponpipom

Narindar N Girotra

Helen M Organ

Tesfaye Biftu

Hyun O Ok

Elbert E Harris

Edward W Tristram

Helmut H Mrozik

Danqing D Feng

XiaoXia Qian

Thomas L Shih

Gui-Bai Liang

Stephanie L Witkin

Eugene D Thorsett

Conrad P Dorn

Byron H Arison

Steven L Colletti

Jinlong Jiang

Peter T Meinke

Robert J DeVita

Eric E Allen

Robert L Bugianesi

Roy G Smith

Joung L Goulet

Francis J Dumont

Yi Tien Yang

Mary Ann Powles

Judith M Pisano

Paul J Hodges

Prasun K Chakravarty

Arnab Kumar Chatterjee

Richard Berger

Dennis M Schmatz

Advait Suresh Nagle

Sandhya Kortagere

Richard B Toupence

Sriram Tyagarajan

Erkang Fan

Mark A Holmes

Daniel Warner

Akhil Vaidya

Donald Hupe

Louis L Zuegner, Iii, Legal Representative

Howard C H Kuo

Tesfaye Bitfu

Jeremy Burrows

Bonnie Louridas

Michael H Fischer

Tomoyo Kato

Huyn O Ok

Alison J Frontier

The present invention is related to a use of pyrazole derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to pyrazole derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation.

Anti-malarial agents

The present invention relates to Mannich base antimalarial aminoalkylphenol compounds and their use against protozoa of the genus, particularly emerging strains of drug-resistant Plasmodia. This invention further relates to compositions containing such compounds and a process for making the compounds. This and other aspects of the invention are realized upon review of the entire specification.

Aminoalkylphenols, methods of using and making the same

Compounds described by the Formula (I): (I) or pharmaceutically acceptable salts, or N-oxides thereof. The compounds are useful for the treatment and prevention of protozoal diseases in mammals and birds. A method for controlling coccidiosis in poultry comprises administering an effective amount of the compound alone, or in combination with one or more anticoccidial agent(s). A composition for controlling coccidiosis in poultry comprises the compound alone, or in combination with one or more anticoccidial agent(s). Methods for the treatment and prevention of mammalian protozoal diseases, such as, for example, toxoplasmosis, malaria, African trypanosomiasis, Chagas disease, and opportunistic infections comprise administering the compound alone, or in combination with one or more antiprotozoal agent(s). 

Antiprotozoal imidazopyridine compounds

Compounds described by the Formula (I) or (II): or pharmaceutically acceptable salts, or N-oxides thereof. The compounds are useful for the treatment and prevention of protozoal diseases in mammals and birds. A method for controlling coccidiosis in poultry comprises administering an effective amount of the compound alone, or in combination with one or more anticoccidieal agent(s). A composition for controlling coccidiosis in poultry comprises the compound alone, or in combination with one or more anticoccidial agent(s). Methods for the treatment and prevention of mammalian protozoal diseases, such as, for example, toxoplasmosis, malaria. African typanosomiasis, Chagas disease, and opportunistic infections comprise administering the compound alone, or in combination with one or more antiprotozoal agent(s). 

Certain novel 4-substituted N-acylated piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.

Acylated piperidine derivatives as melanocortin-4 receptor agonists

The present invention relates to novel nodulosporic acid derivatives, which are acaricidal, antiparasitic, insecticidal and anthelmintic agents.

C1 to C4 side chain modified nodulisporic acid analogs

Trisubstituted pyrroles are antiprotozoal agents useful in the treatment and prevention of protozoal diseases in human and animals, including the control of coccidiosis in poultry.

Aliphatic hydroxy substituted piperidyl diaryl pyrrole derivatives as antiprotozoal agents

Aliphatic amine substituted piperidyl diaryl pyrrole derivatives as antiprotozoal agents

Nonacyclic nodulisporic acid derivatives

Diaryl piperidyl pyrrole derivatives as antiprotozoal agents

There are disclosed compounds of formula (I)

Antagonists of gonadotropin releasing hormone

The present invention is directed to certain naphtho-fused lactams of the general structural formula:

Naphtho-fused lactams promote release of growth hormone

There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.

Growing community of inventors

Mountainside, NJ, United States of America

Matthew J Wyvratt