Wisconsin Alumni Research Foundation

Matthew J Wanat

Robert M Corn

Bernard Weisblum

Andrew T Ulijasz

Matthew G Erickson

Emily A Smith

Disclosed are methods for making surface plasmon resonance-capable arrays wherein molecules, such as proteins or nucleic acids, or cells, are adhered to a metal substrate. The metal substrates are modified by depositing an &#x3c9;-modified alkanethiol monolayer to the substrate and then contacting the &#x3c9;-modified monolayer with a heterobifunctional linking compound. Biomolecules or cells can then be attached to the heterobifunctional linking compound. Also disclosed are arrays wherein glutathione-containing molecules are immobilized on the substrate and GST-containing molecules are then specifically immobilized onto the substrate, taking advantage of the affinity between glutathione and GST.

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Madison, WI, United States of America

Matthew J Wanat