Chemocentryx, Inc.

Arcus Biosciences, Inc.

Matthew J Walters

Penglie Zhang

Jay Patrick Powers

Manmohan Reddy Leleti

Venkat Reddy Mali

Ju Yang

Viengkham Malathong

Hiroko Tanaka

Christopher W Lange

Rebecca M Lui

Yandong Li

Dean R Dragoli

Daniel J Dairaghi

Joanne Tan

Jaroslaw Kalisiak

Stephen W Young

Akshata R Udyavar

Jarek Kalisiak

Amy Elizabeth Anderson

Devika Ashok

Daniel M DiRenzo

Daniel Dairaghi

The present disclosure provides methods of treating a cancer in a subject having an established adenosine fingerprint. An established adenosine fingerprint includes assessing the blood concentration of one or more adenosine machinery proteins, assessing the enzymatic activity of one or more adenosine machinery proteins, and/or assessing the tumor expression level of adenosine machinery proteins. The methods disclosed herein include administering to said subjects a therapeutic agent selected from the group consisting of an agent targeting the extracellular production of adenosine, and an agent antagonizing the activation by adenosine of one of its receptors.

Treatment of cancer utilizing an identified adenosine fingerprint

Compounds of formula (I) are provided which are useful in the treatment of diseases or conditions modulated at least in part by CCR6: 

CCR6 compounds

Growing community of inventors

Pacifica, CA, United States of America

Matthew J Walters