Mayo Foundation for Medical Education and Research

Eberhard Karls Universitaet Tuebingen

Helmholtz Zentrum Munchen Deutsches Forschungszentrum Fur Gesundheit Und Umwelt

Helmholtz Zentrum Muenchen Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt Gmbh

Alnylam Pharmaceuticals, Inc.

Eberhard-karls-universitat Tubingen

Matthew J Farrer

Hans-Peter Vornlocher

Jan O Aasly

Zbigniew K Wszolek

Thomas Meitinger

Elisabeth Kremmer

Tim Matthias Strom

Marius Ueffing

Jennifer M Kachergus

Ryan Uitti

Zibigniew Wszolek

Mary M Hulihan

Sara J Lincoln

Alexander Zimprich

Nadja Patenge

Friedrich Asmus

Petra Herzig

Thomas Gasser

Christian Johannes Gloeckner

Saskia Biskup

Demetrius Maraganore

Christian J Gloeckner

Petra Leitner

A polynucleotide consisting of the base sequence of SEQ ID NO:2, or a complementary strand thereto, wherein the X is one of the group being defined by the bases A, C or T. A primer and a probe specific for that polynucleotide, wherein the primer and/or probe contains at least 10 consecutive nucleotides, and finally use of the probe for proving parkinsonism inheritance.

LRRK2 polynucleotides

The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detection and treatment of neurodegenerative disorders, such as Parkinson disease (PD) including, without limitation, sporadic PD, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), and other synucleinopathies and/or tauopathy as well as several polymorphisms and mutations in the KASPP/LRRK2 gene segregated with PD.

KASPP (LRRK2) gene, its production and use for the detection and treatment of neurodegenerative disorders

A polynucleotide consisting of the base sequence of SEQ ID NO: 2, or a complementary strand thereto, wherein the X is one of the group being defined by the bases A, C or T. A primer and a probe specific for that polynucleotide, wherein the primer and/or probe contains at the least 10 consecutive nucleotides, and finally use of the probe for proving parkinsonism inheritance.

Method of screening for LRRK2-related parkinsonism inheritance

Polynucleotide

Growing community of inventors

Jacksonville, FL, United States of America

Matthew J Farrer