Carl Zeiss Meditec Gmbh

University of California

Carl Zeiss Meditec Ag

Carl Ziess Meditec, Inc.

Carl Zeiss Ag

Carl Zeiss Industrial Metrology, LLC

Matthew J Everett

Keith E O'Hara

Yan Zhou

Scott A Meyer

Alexandre R Tumlinson

Martin Hacker

Luiz B Da Silva

Tilman Schmoll

Billy W Colston

Paul Francis Stetson

Utkarsh Sharma

Nathan Shemonski

Yue Qiu

Michael Kempe

Claus Flachenecker

Rick A Williams

Daniel Bublitz

Mary K Durbin

Jonathan David Oakley

Jochen Straub

Tobias Schmitt-Manderbach

Conor Leahy

Lingfeng Yu

Dennis L Matthews

Paul J Weber

Harihar Narasimha-Iyer

Yuan Liu

Muzammil A Arain

Robert W Knighton

Steven R Visuri

Steve B Brown

Michael Totzeck

Jonathan Noah Simon

Xing Wei

Shahram Shawn Dastmalchi

Fred Paul Milanovich

Joseph P Fitch

Luis De Sisternes

Marcin B Bauza

Qienyuan Zhou

Csaba Farkas

David Nolan

Jennifer Y Luu

Alwin H Kolster

Ujwal S Sathyam

Gregory G Anderson

Keith Brock

Priya Kulkarni

Lars Omlor

Christopher J R V Baker

Göran Anders Johansson

Gary Franklin Stone

Sophie Kubach

Jochen M M Horn

James Foley

Dale L James

Joseph Grau Davis

Howard Nathel

Niranchana Manivannan

Sunny Virmani

Hueyming Tzeng

Chris Baker

Kodumudi Vendateswaran

Daniel Fried

Kevin Meng

Jeffery N Roe

Harry E Cartland

Katherine Makedonsky

Zubir Khan

Gary Lee

Robert Sprowl

Jeffrey Schmidt

Michael Chen

Archana Kolli

Pranav Malvania

Muhammad K Al-Qaisi

Richard Orlowski

Scott Chang

Benjamin Kwok

Ali Fard

Keith E O'hara

Keith O'hara

Gregory Anderson

Jennifer Luu

Christopher JRV Baker

Systems and methods for improved interferometric imaging are presented. One embodiment is a partial field frequency-domain interferometric imaging system in which a light beam is scanned in two directions across a sample and the light scattered from the object is collected using a spatially resolved detector. The light beam could illuminate a spot, a line or a two-dimensional area on the sample. Additional embodiments with applicability to partial field as well as other types of interferometric systems are also presented.

Frequency-domain interferometric based imaging systems and methods

An ophthalmic imaging system provides an automatic focus mechanism based on the difference of consecutive scan lines. The system also provides of user selection of a focus point within a fundus image. A neural network automatically identifies the optic nerve head in an FA or ICGA image, which may be used to determine fixation angle. The system also provides additional scan tables for multiple imaging modalities to accommodate photophobia patients and multi-spectrum imaging options.

Patient tuned ophthalmic imaging system with single exposure multi-type imaging, improved focusing, and improved angiography image sequence display

A scan imaging system has a scanning component that receives light from a light source, and creates a scanning beam that is directed by an optic train to a sample to be imaged. A camera captures light returning from the sample to construct an image. Reflexes on a target lens within the optic train are prevented by one or more light blocks. A first light block, imaged to the target lens, is positioned in alight path from the light source to the scanning component to create a first moving dark zone on the target lens through which the scanning beam from the scanning component to the sample may not pass. A second light block, also imaged to the target lens, is positioned in alight path from the sample to the collector to create a second moving dark zone on the target lens through which light returning from the sample may not pass. The moving dark zones maintain the scanning beam separate from the returning light on the target lens.

Slit-scanning fundus imager enhancements

A low cost fundus camera uses LED light sources placed adjacent the camera's imaging stop, and thereby eliminates the need for optics for introducing the light source to the camera's optical path. Lens reflex in the pupil relay is avoided by using only reflective optics in the pupil relay. Reflex from the LED is mitigated by actuating each LED separately, one at a time, and capturing a separate image with each actuated LED. Reflex-free regions of each captured image are extracted and combined to create a composite reflex-free image.

Low cost fundus imager with integrated pupil camera for alignment aid

Systems and methods for Broad Line Fundus Imaging (BLFI), an imaging approach that is a hybrid between confocal and widefield imaging systems, are presented. These systems and methods are focused on improving the quality and signal of broad line fundus images or imaging methods to create high contrast and high resolution fundus images. Embodiments related to improved pupil splitting, artifact removal, reflex minimization, adaptable field of view, instrument alignment and illumination details are considered.

Systems and methods for broad line fundus imaging

An optical coherence tomography (OCT) system () is used to inspect bonding points (A,B,C) sandwiched between two materials (layersof e.g. displays). The OCT differentiates between a bonding point, e.g. a weld, and air gaps between the two materials. The bonding points are identified as breaks in the air gap between the materials. By extracting various physical characteristics of the bonding points and the gap between the two materials, the present system determines whether the bonding is faulty.

Inspection of bonding quality of transparent materials using optical coherence tomography

An ophthalmic imaging system has a specialized graphical user interface GUI to convey information for manually adjusting control inputs to bring an eye into alignment with the device. The GUI provides additional information such as laterality, visual alignment overlay aids, and live video feeds. The system further applies automatic gain control to fundus images, synchronizes itself with other ophthalmic systems on a computer network, and provides an optimized image load and display system.

Systems and methods for improved ophthalmic imaging

Ophthalmic imaging systems, particularly slit-scanning ophthalmo-scopes, are capable of characterizing refraction over the entire field of view of the system. Light from the light source of the system illuminates a region of the eye and the returning light is measured on a detector. The deviation of the location of the returning light from a predetermined location on the detector is measured. The deviation corresponds to the mismatch between the refractions of the imaging system and the eye. The light can be scanned across the full field of view to characterize the entire field. A second illumination source traveling along a second illumination path can be used to improve the characterization. The characterization can be of use for optimizing the focus of the instrument and for assessing the condition of the eye, including assessing myopia and astigmatism in the periphery.

Systems and methods for characterizing refraction with ophthalmic imaging systems

Improved scanning ophthalmoscopes for scanning the retina of an eye are discussed in the present disclosure. One example scanning ophthalmoscope includes an uncollimated light source, a first scanning element, a second scanning element, a slit of a first aspherical mirror, and a second aspherical mirror. The uncollimated light source produces a beam of light to illuminate the retina. The beam of light is relayed from the first scanning element onto the second scanning element by the slit of the first aspherical mirror. The second aspherical mirror relays the beam of light from the second scanning element to the pupil of the eye.

Reflective ultra-wide field fundus imager

An ophthalmic imaging system provides a user interface to facilitate the montaging of scan images collected with various imaging modalities, such as images collected with a fundus imaging system or an optical coherence tomography (OCT) system. The amount of each constituent image used in the montage is dependent upon its respective quality. During the collecting of scans (constituent images) for montaging, any scan may be designated for rescanning, such as if its current quality is deemed less than sufficient. In the case of using an OCT system to collect constituent images (e.g., cube scans), the scanned region of a constituent image may be modified based on physical characteristics of the eye being scanned.

Systems and methods for improved montaging of ophthalmic imaging data

Various systems and methods for sequential angle illumination to achieve ultra-high resolution optical coherence tomography (OCT) images. One example OCT system includes a light source, a beam divider, sample arm optics, a detector, and a processor. The light source generates a light beam to illuminate the sample. The beam divider separates the light beam into reference and sample arms. The sample arm optics sequentially illuminates a location in the sample with the light beam from different angles. The detector receives light returned from the reference arm and the sample illuminated at each angle and generates signals. The processor combines the signals to generate an image, which has a transverse resolution that is higher than the transverse resolution achieved from the signal generated from a single angle.

Systems and methods for improved OCT measurements

An efficient OCT data collection and processing method for obtaining a high-axial-resolution image with explicit ranging over an extended depth is described. The method includes collecting a first dataset at a transverse location of the sample. The first dataset comprises spectra of a bandwidth (&#x394;k) sampled at a spectral sampling interval (dk). A second dataset comprising spectra of a bandwidth (&#x394;k) sampled at a spectral sampling interval (dk) is collected. The bandwidth &#x394;kis less than &#x394;kand spectral sampling interval dkis less than dk. The first and the second datasets are processed to generate at least one A-scan with an axial resolution higher than the axial resolution corresponding to the bandwidth &#x394;kand a depth range larger than the depth range provided by sampling interval dk.

Efficient sampling of optical coherence tomography data for explicit ranging over extended depth

Growing community of inventors

Livermore, CA, United States of America

Matthew J Everett