Owlstone Medical Limited

Owlstone Limited

Owlstone Nanotech Inc

Ownstone Medical Limited

Matthew Hart

Max D Allsworth

John Matthew Somerville

Andrew H Koehl

Alastair Taylor

Ashley Wilks

Stephen Hartwell

Antoni Negri

Danielle Toutoungi

Jon Pearson

Richard Orrell

Jeremy Spinks

Martin Holden

Alison Hart

Mike Black

Iva Manasi

Daniel Melhirst

Lara E Jamieson

Lara Jamieson

A method of manufacture for a ion mobility filter is disclosed. The method of manufacturing an ion filter for a spectrometry system includes providing a sheet of conductive material and defining a plurality of ion filters on the sheet. The definition of the plurality of ion filters is achieved by forming an electrode layer for each ion filter on the sheet, where each electrode layer comprises at least one ion channel and an isolation channel surrounding the at least one ion channel. A support layer on each electrode layer is also formed. Each support layer comprises an aperture at least partially aligned with the at least one ion channel. The ion filter is then separated. The risk of contaminants entering the at least one ion channel when separating the ion filters is reduced by surrounding the at least one ion channel with the isolation channel.

Method of manufacture for an ion mobility filter

A corona discharge ionizer device which emits ions generated by corona discharge to a gas flow to be ionized includes a discharge electrode having a pin configured tip portion. A second grid electrode positioned at a spaced distance from the discharge electrode is provided. The grid electrode is preferably formed from a sheet configured material which has at least one hole formed therein adapted and configured to permit the gas flow to pass therethrough. A power supply is coupled to the discharge electrode and grid electrode configured cause ion emission from the discharge electrode. The power supply is preferably an alternating current power supply configured to produce an alternating electric field region in close proximity to the tip portion of the discharge electrode sufficient to cause avalanche breakdown in the gas flowing in close proximity to the tip portion of the discharge electrode.

Corona ionization apparatus and method

An ion filter and a method of manufacturing an ion filter. The method including providing a monolithic structure; selectively removing regions of the structure, to form a pair of electrodes defining at least one ion channel therebetween. The electrodes are preferably mechanically connected at one or more locations by a portion of the structure; wherein the connecting portion of the structure provides a higher electrical impedance than the filter would provide without such a mechanical connection, to thereby electrically separate the electrodes.

Interdigitated electrode configuration for ion filter

Ion filter for FAIMS fabricated using the LIGA technique. The ion filter is manufactured using a metal layer to form the ion channels and an insulating support layer to hold the structure rigidly together after separation of the metal layer into two electrodes.

Field asymmetric ion mobility spectrometry filter

An apparatus, system and method for detecting, identifying, classifying and/or quantifying chemical species in a gas flow using a micro-fabricated ion filter coupled to a system adapted to apply drive signals to the ion filter. Coupled to the ion filter is a system adapted to measure the output of the ion filter, which in turn is coupled to a system adapted to extract numerical parameters from the measured output of the ion filter to facilitate chemical detection, identification, classification and/or quantification of the gas flow.

Field asymmetric ion mobility spectrometry system

An ion mobility gas detector apparatus including a detector core, an inlet gas path, an exhaust gas path, a source of diluent gas, and at least one or more sensors for measuring temperature, pressure and humidity of gas streams. Further included is a mixing mechanism adapted to mix at least first and second gas streams in response to one or more sensor measurements. A controller is provided for applying drive signals to the detector core.

Sensor apparatus and method for use with gas ionization systems

Corona ionization device and method

An ion filter () for use in ion mobility spectrometry is described, together with a method for manufacturing the filter. The filter () is manufactured by removing portions from a monolithic structure to form a pair of electrodes which remain mechanically connected. The connecting portion () provides sufficient electrical impedance between the electrodes to effectively electrically separate the electrodes. The connecting portion may be doped or chemically modified to obtain a desired impedance, or this may be obtained through appropriate selection of physical dimensions.

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London, United Kingdom

Matthew Hart