Wyeth

Matthew Gregory Bursavich

Adam Matthew Gilbert

Phaik-Eng Sum

Fuk-Wah Sum

Lijing Chen

Lee Dalton Jennings

Dennis William Powell

David Brian How

Joshua James Sabatini

Yixian Zhang

Scott Lee Kincaid

Gulnaz Khafizova

Jeremy Clemens

Sabrina Lombardi

Leif Mark Laakso

Yongbo Hu

The present invention relates to 8-Hydroxyquinoline Compounds; compositions comprising an 8-Hydroxyquinoline Compound; and methods for treating or preventing a metalloproteinase-related disorder, such as, an arthritic disorder, osteoarthritis, malignant neoplasm, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, atherosclerosis, age-related macular degeneration, myocardial infarction, a corneal ulceration, an ocular surface disease, hepatitis, an aortic aneurysm, tendonitis, a central nervous system disorder, abnormal wound healing, angiogenesis, restenosis, cirrhosis, multiple sclerosis, glomerulonephritis, graft versus host disease, diabetes, an inflammatory bowel disease, shock, invertebral disc degeneration, stroke, osteopenia or a periodontal disease or comprising administering an effective dose of an 8-Hydroxyquinoline Compound to a mammal in need thereof.

8-hydroxyquinoline compounds and methods thereof

The present invention relates to compounds of formula I: wherein R, R, R, R, R, and Rare defined herein.

Anilino-pyrimidine analogs

Growing community of inventors

Tuckahoe, NY, United States of America

Matthew Gregory Bursavich