Ptc Therapeutics, Inc.

F. Hoffmann-la Roche Ag

Hoffmann-la Roche Inc.

Matthew G Woll

Gary Mitchell Karp

Jana Narasimhan

Nanjing Zhang

Anthony A Turpoff

Hongyan Qi

Emmanuel Pinard

Hasane Ratni

Nikolai A Naryshkin

Xiaoyan Zhang

Marla L Weetall

Amal Dakka

Tianle Yang

Ellen Welch

Soongyu Choi

Anuradha Bhattacharyya

Xin Zhao

Guangming Chen

Luke Green

Suresh D Babu

Anthony R Mazzotti

Nadiya Sydorenko

Jigar S Patel

Young-Choon Moon

Zhenrong Xu

Aleksey I Gerasyuto

Hongyu Ren

Scott J Barraza

Chang-Sun Lee

Sergey Paushkin

Chunshi Li

Wuming Yan

Michael Andrew Arnold

Vara Prasad Venkata Nagendra Josyula

Ramil Y Baiazitov

Minakshi B Jani

Sean Wesley Smith

Jiashi Wang

Christie Morrill

Lukiana Amedzo

Song Xiao Huang

Md Rauful Alam

Andrew J Kassick

John David Baird

Olya Ginzburg

Srinivasa Peddi

Arthur Branstrom

Anthony A Yurpoff

Nathaniel T Kenton

Sudipta Pal

Nicholas W Mszar

Tom Tuan Luong

Anthony Turpoff

Nicole Risher

Rauful Alam

Gang Wang

Song Huang

Antony Allan Turpoff

Nicholas Walter Mszar

Maria L Weetall

Nikolai Naryshkin

The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted bicyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

Compounds for treating Huntington's disease

The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted benzothiazole compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

Heteroaryl compounds for treating Huntington's disease

The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted bicyclic heterocyclic and heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

Heterocyclic and heteroaryl compounds for treating Huntington's disease

The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I) or Formula (II), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

Provided herein are compounds of Formula (I): and forms thereof, wherein w, w, w, w, w, wand ware as defined herein, including compositions thereof and uses therewith for treating spinal muscular atrophy.

Compounds for treating spinal muscular atrophy

The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted bicyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. 

The present description relates to a method or use of a compound for treating or ameliorating HD (Huntington's Disease) in a subject in need thereof comprising administering to the subject an effective amount of a compound of Formula (I): or a form thereof, wherein w, w, w, w, w, wand ware as defined herein. In particular, the present description relates to a method of use of a compound of Formula (I) or a form or composition thereof for treating or ameliorating HD in a subject in need thereof comprising, administering an effective amount of the compound or a form or composition thereof to the subject.

Methods for treating Huntington's Disease

Provided herein are compounds of Formula (I): 

The present invention provides compounds of formula (I) wherein A, B, X, Y, R1 and R2 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments. 

Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy. In a specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN2 into mRNA that is transcribed from the SMN2 gene. In another specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 into mRNA that is transcribed from the SMN1 gene. In yet another embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 and SMN2 into mRNA that is transcribed from the SMN1 and SMN2 genes, respectively.

Provided herein are compounds of Formula (I): and forms thereof, including compositions thereof and uses therewith for treating spinal muscular atrophy.

The present description relates to compounds and forms and pharmaceutical compositions thereof and methods for use thereof to treat or ameliorate bacterial infections caused by wild-type and multi-drug resistant Gram-negative and Gram-positive pathogens.

Antibacterial compounds and methods for use

Growing community of inventors

Dunellen, NJ, United States of America

Matthew G Woll