Merck Patent Gmbh

Merck Sharp + Dohme Corp.

Msd K.k.

Serenex, Inc.

Matthew G Jenks

Henry Yu

Thomas E Richardson

Robert J Foglesong

Brian H Heasley

Pandi Bharathi

Steven E Hall

Toshihiro Sakamoto

Tony Siu

Yoshio Ogino

Roy Wendell Ware

Nobuhiko Kawanishi

Weiming Fan

Michael Robert Peel

Lindsay A Hinkley

Michael James Malaska

Bharathi Pandi

Yu Onozaki

Hao Liu

Joseph A Moore, Iii

Klass P Hardeman

Thomas F N Haxell

Shuliang Lee

Joseph A Iii Moore

Novel benzamide derivatives of formula (I) wherein W, W, Rto Rand X have the meaning according to the claims, are positive allosteric modulators of the FSH receptor, and can be employed, inter alia, for the treatment of fertility disorders.

Benzamide derivatives as modulators of the follicle stimulating hormone

The instant invention provides for substituted fused naphthyridine derivatives that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.

Inhibitors of Akt activity

Alkyl-linked nucleotide non-homogeneous solid supports and nucleotide affinity media comprising an alkyl-linked nucleotide are provided. The linker is generally a hydrophobic linker that can be a 3, 4, 5, 6, 7, 8, 9, 10, or a longer carbon chain. Also included in the invention are methods for synthesis of an alkyl-linked nucleotide, nucleotide affinity media and methods of use thereof for affinity chromatography and screening methods.

Alkyl-linked nucleotide compositions

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Durham, NC, United States of America

Matthew G Jenks