Essen Instruments, Inc.

Intellicyt Corporation

Sartorius Bioanalytical Instruments, Inc.

Matthew Ferris

Kathy Lou Rowlen

Kathy Rowlen

A flow cytometry system and method for quantification of fluorescently labeled virus particles smaller than 1 micron in size measures and controls sample fluid flow rate to an investigatory flow cell at a rate below 5000 nanoliters per minute and calculates in real time particle concentration in the sample fluid using measured flow rated data flow rate data and with correction for sample fluid flow rate fluctuations.

Flow measurement and control for improved quantification of particles in flow cytometry

The present invention relates to methods that enable improved accuracy for quantitative particle counting in a flowing liquid stream. The methods of the present invention utilize the real-time measurement of flow rates and flow rate control through feedback mechanisms to improve quantification, and this improved quantification translates to more accurate particle counting. In certain embodiments, particles being counted are biological particles in a liquid sample, such as viruses.

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Louisville, CO, United States of America

Matthew Ferris