Ucb Biopharma Sprl

Ucbbiopharma Srl

Pfizer Corporation

Sanofi

Agouron Pharmaceuticals, Inc.

Ziarco Inc.

Matthew Duncan Selby

Zhaoning Zhu

Daniel Christopher Brookings

Michael Alan Shaw

Joanna Rachel Quincey

Mark Daniel Calmiano

Paul Anthony Stupple

Boris Kroeplien

James Andrew Johnson

David Anthony Price

Martin Clive Hutchings

Fabien Claude Lecomte

John Robert Porter

James Thomas Reuberson

Jag Paul Heer

Lyn Howard Jones

Charles Eric Mowbray

Jean Keyaerts

Anne Marie Foley

Michael Deligny

James Madden

Dominique Louis Leon Swinnen

Laurent Schio

Julien Alistair Brown

Victoria Elizabeth Jackson

Craig Johnstone

Bruno Filoche-Romme

Elizabeth Pearl Jones

Jonathan Bentley

Gareth Neil Brace

Teresa De Haro Garcia

Yann Foricher

Sophie Jadot

Mengyang Xuan

Malcolm Mac Coss

Yves Evrard

Jonathan Mark Bentley

Rikki Peter Alexander

Timothy John Norman

Richard David Taylor

Martin Alexander Lowe

Helen Tracey Horsley

Laura Gleave

Ellen Olivia Gallimore

Alexander Heifetz

Hervé Jean Claude Deboves

Thomas Paul Cain

Deborah Leigh

Laura Jane Gleave

Praful Tulshi Chovatia

Volkmar Wehner

Uwe Heinelt

Malcolm Maccoss

Andrew Simon Bell

Judi Charlotte Neuss

Nigel Alan Swain

Richard Jeremy Franklin

Alistair James Henry

Yogesh Anil Sabnis

William Ross Pitt

Gregory Foulkes

Ian Yule

Oliver Philps

Prafulkumar Tulshibhai Chovatia

Giancarlo Trani

Sabine Defays

Gregory William Haslett

Robert James Townsend

Nathalie Van Houtvin

Sarah Emily Richardson

Pfrafulkumar Tulshibhai Chovatia

Monika-Sarah Elisabeth Dorothea Schulze

Konstantinos Rampalakos

Rickki Lee Connelly

Selvaratnam Suganthan

Paul Jonathan Hickford

Adam Peter Smalley

Rose Elizabeth Chappell

Veronique Durieu

Craig Miller

Darshan Gunvant Vaidya

Laura Claire Reed

Anthony John Richardson

Dominique Louis Swinnen

Charlotte Alice Lane

David Howard Williams

Herve Jean Deboves

Ian Andrew Yule

Craig Adrian Miller

A series of substituted fused bicyclic imidazole derivatives, including imidazo[1,2-a]pyridine derivatives and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

Imidazopyridine derivatives as IL-17 modulators

Thiophene derivatives of formula (I) and a pharmaceutically acceptable salt thereof are provided. These compounds have utility for the treatment or prevention of disorders caused by IgE, such as allergy, type 1 hypersensitivity or familiar sinus inflammation.

Thiophene derivatives for the treatment of disorders caused by IgE

A series of fused pentacyclic imidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. In particular, the present invention is concerned with 6, 7-dihydro-7, 14-methanobenzimidazo[1, 2-b][2,5]benzodiazocin-5(14H)-one derivatives and analogs thereof.

Fused pentacyclic imidazole derivatives

A series of substituted spirocyclic 2-oxoindoline derivatives, and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders. 

Spirocyclic indolines as IL-17 modulators

A series of fused pentacyclic imidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. In particular, the present invention is concerned with 6,7-dihydro-7,14-methanobenzimidazo[1,2-b][2,5]benzodiazocin-5(14H)-one derivatives and analogs thereof.

A series of substituted benzimidazole, imidazo[1,2-&#x3b1;]pyridine and pyrazolo[1,5-&#x3b1;]pyridine derivatives, and analogs thereof, being potent modulators of human TNF&#x3b1; activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

Fused imidazole and pyrazole derivatives as modulators of TNF activity

A series of tricyclic benzimidazole derivatives, in particular dihydro-1H-imidazo [1,2-a]benzimidazole, dihydro-1H-pyrrolo [1,2-a]benzimidazole, dihydro-1H-pyrazino[1,2-a]benzimidazole, dihydro-1H-[1,4]oxazino[4,3-a]benzimidazole and dihydrothiazolo[3,4-a]benzimidazolem, and analogs thereof, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

Fused tricyclic benzimidazoles derivatives as modulators of TNF activity

A series of substituted benzimidazole, imidazo[1,2-a]pyridine and pyrazolo[1,5-a]pyridine derivatives, and analogues thereof, being potent modulators of human TNF&#x3b1; activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

A series of benzimidazole derivatives, being potent modulators of human TNF&#x3b1; activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

TNF -&#x3b1; modulating benzimidazoles

A series of imidazo[1,2-a]pyrazine derivatives, being potent modulators of human TNF&#x3b1; activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. The imidazo[1,2-a]pyrazine derivatives of the disclosure are of general formula 

Substituted imidazo[1,2-a]pyrazines as TNF activity modulators

A series of imidazo[1,2-a]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. 

Imidazopyridine derivatives as modulators of TNF activity

This invention relates to pyrazole derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivative thereofs, wherein R1 to R4 are defined in the description, and to processes for the preparation thereof, intermediates used in their preparation of, compositions containing them and the uses of such derivatives. The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof. As such the compounds of the present invention are useful in the treatment of a variety of disorders including those in which the inhibition of reverse transcriptase is implicated. Disorders of interest include those caused by Human Immunodeficiency Virus (HIV) and genetically related retroviruses, such as Acquired Immune Deficiency Syndrome (AIDS).

Pyrazole derivatives

This invention relates to pyrazole derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivative thereofs, wherein R1 to R4 are defined in the description, and to processes for the preparation thereof, intermediates used in their preparation of, compositions containing them and the uses of such derivatives. The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof. As such the compounds of the present invention are useful in the treatment of a variety of disorders including those in which the inhibition of reverse transcriptase is implicated. Disorders of interest include those caused by Human Immunodificiency Virus (HIV) and genetically related retroviruses, such as Acquired Immune Deficiency Syndrome (AIDS).

This invention relates to pyrazole derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivative thereof, wherein Rto R, n W, X and Y are defined in the description, and to processes for the preparation thereof, intermediates used in their preparation of, compositions containing them and the uses of such derivatives. The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof. As such the compounds of the present invention are useful in the treatment of a variety of disorders including those in which the inhibition of reverse transcriptase is implicated. Disorders of interest include those caused by Human Immunodificiency Virus (HIV) and genetically related retroviruses, such as Acquired Immune Deficiency Syndrome (AIDS).

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Slough, United Kingdom

Matthew Duncan Selby