Transmedics, Inc.

Matthew De Remer

Scott W Newell

Waleed H Hassanein

Tamer I Khayal

Richard Bringham

Stanley Kyi

John Sullivan

Robert Havener

Robert Fishman

Mark Anderson

Ihab Abdel Fattah

Anas Abdelazim

Michael Van Driel

Doug Harriott

Paul Murray

Ron Taylor

Tom Bishop

Thomas H Bishop

Ronald Taylor

Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

Systems and methods for ex vivo lung care

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Allston, MA, United States of America

Matthew De Remer