Emulate, Inc.

Becton Dickinson and Company Limited

Tearlab Research, Inc.

Lockheed Martin Corporation

Leidos Innovations Technology, Inc.

Microlab Diagnostics, Inc.

Matthew Daniel Solomon

Daniel Levner

Christopher David Hinojosa

Josiah Daniel Sliz

Guy Robert Thompson, Ii

Christian Alexander Potzner

Patrick Sean Tuohy

Petrus Wilhelmus Martinus Van Ruijven

Jason Paul Hayes

Matthew Springer

Peter Van Ruijven

Benjamin D Sullivan

Norman Wen

James P Landers

Joshua Gomes

Alexander George Lastovich

James L Schram

Orion N Scott

Brian Root

Jacob Freake

Doug Sabin

Joan Marie Bienvenue

David Saul

Erol Craig Harvey

Douglas J South

Michael E Egan

An-Chi Tsuei

Steve Zmina

Rex Young Nielson

Pauline Elizabeth Bell

Anita Quinn

Matthew James Springer

Lincoln Belcourt

Paul Kinnon

Eric Donsky

Brandon Westerberg

Fred Harry Davis

Carl Gang Chen

Graeme John Bullock

Sebastiaan Garst

Derek Lee

Joanna Slowinska

Peter Munster

Jason Hayes

Christian Potzner

Melissa Lee

Andreas Knaack

Adam Ernest Donath

Sasha Miu

Michael Wilkinson

James Lee Schram

Guy Robert Thompson Ii

Petrus Martinus Van Ruijven

Doug Doug

Michael Egan

Guy Robert Thompson

Systems, methods, and devices for analyzing small volumes of fluidic samples, as a non-limiting example, less than twenty microliters are provided. The devices are configured to make a first sample reading, for example, measure an energy property of the fluid sample, for example, osmolality, make a second sample reading, for example, detecting the presence or concentration of one or more analytes in the fluid sample, or make both the first sample reading and the second sample reading, for example, measuring the energy property of the fluid sample as well as detecting the presence or concentration of one or more analytes in the fluid sample.

Systems and methods for integration of microfluidic tear collection and lateral flow analysis of analytes of interest

An assembly for preparing a specimen is provided that may be configured to determine the presence of at least one microorganism specie in the specimen. The assembly may include a pipette configured to acquire a specimen from a sample and an imaging cartridge configured to be in fluid communication with the pipette. The imaging cartridge and the pipette may be configured to be irreversibly coupled such that the specimen is bio-contained within the imaging cartridge and the pipette when the imaging cartridge and pipette are coupled together. Associated methods of use are also provided.

Imaging cartridge, pipette, and method of use for direct sputum smear microscopy

The invention relates to a perfusion manifold assembly that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with an assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.

Perfusion manifold assembly

Drop-to-drop connection schemes are described for putting a microfluidic device in fluidic communication with a fluid source or another microfluidic device, including but not limited to, putting a microfluidic device in fluidic communication with the perfusion manifold assembly.

Droplet fluid connections

The invention relates to a perfusion manifold assembly that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with an assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate. The invention further relates to a drop-to-drop connection scheme for putting a microfluidic device in fluidic communication with a fluid source or another microfluidic device, including but not limited to, putting a microfluidic device in fluidic communication with the perfusion manifold assembly.

A microfluidic cartridge can include at least one nucleic acid analysis portion. Each nucleic acid analysis portion can include a fluidic network being configured for micro-liter volumes or less, a sample input at the beginning of the fluidic network, a plurality of vent ports and fluidic channels in the fluidic network configured to effectuate hydrodynamic movement within the fluidic network, an extraction mixture reservoir in the fluidic network, a mixing chamber in the fluidic network, an amplification chamber in the fluidic network, and a separation channel in the fluidic network. A nucleic acid analyzer can be capable of performing nucleic acid analysis using the microfluidic cartridge. A nucleic acid analysis method can be performed using the microfluidic cartridge.

Microfluidic cartridge

A fluid collection device comprising a body comprising a capsule interface, and a capsule configured to interface with the body via the capsule interface and configured to hold a sample receiving chip. The sample receiving chip comprises a substrate that receives an aliquot volume of a sample fluid, wherein the substrate is operatively shaped to receive the aliquot volume of sample fluid through capillary action, and a sample region of the substrate, sized such that the volume of the sample fluid is sufficient to operatively cover a portion of the sample region, whereupon energy properties of the sample fluid can be transduced to produce a sample fluid reading.

Systems and methods for a sample fluid collection device

Growing community of inventors

Hughesdale, Australia

Matthew Daniel Solomon