Biomet Biologics, LLC

Zimmer Gmbh

Dorian, Randel E.

Matthew D Landrigan

Joel C Higgins

Michael D Leach

Jennifer E Woodell-May

Randel E Dorian

James M McKale

Alan David Gray

Krista O'Shaughnessey

Grant Cunningham

David L Suter

Richard Wood Storrs

Scott R King

Matthew Swift

Krista Toler

Trenton Walker

Kyle Kausch

A blood washing system () having a rotor () defining an internal chamber for receiving a multi-component fluid and a skimmer assembly () including a moveable buoy () having an orifice () fluidly connected to an access port for the rotor for selectively withdrawing separated fractions of the multi-component fluid. The multi-component fluid can be fed into the internal chamber before the rotor () can be rotated at a first speed to fractionate the multi-component fluid. A brake can be applied to the rotor to slow rotation of the rotor to a slower second speed or stop rotation of the rotor causing the solid and denser fluid fractions to settle on the bottom wall () of the rotor (). The buoy () can have a specific gravity corresponding to a selected fraction such that the buoy floats on a surface of the selected fraction, wherein the fractions floating on the selected fraction can be withdrawn through the orifice ().

Blood washing and separation system

Methods of treating peripheral vascular disease comprising administering a protein solution site of a defect at least two proteins from the group IL-1ra, sTNF-RI, sTNF-RII, IGF-I, EGF, HGF, PDGF-AB, PDGF-BB, VEGF, TGF-&#x3b2;1, and sIL-1RII. The solution may also comprise white blood cells, platelets, concentrated bone marrow aspirate, and combinations thereof.

Treatment of peripheral vascular disease using protein solutions

Methods and therapeutic compositions for treating respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and devices for administering the therapeutic compositions. Methods for treatment include producing a protein solution, producing a concentrated bone marrow aspirate (cBMA), optionally combining the protein solution and cBMA to form an therapeutic composition, and optionally saturating the autologous therapeutic composition with hydrogen gas, and administering the therapeutic composition to a subject in need thereof. The present methods, compositions and devices are useful for treating COPD and the progression of COPD.

Treatment of inflammatory respiratory disease using biological solutions

Methods for transfusing blood to a mammalian subject. The method includes obtaining a unit of blood, rejuvenating the blood with an enhancement composition, measuring a level of 2,3-diphosphoglycerate in the blood, and delivering the blood to a subject.

Methods for rejuvenating red blood cells

A separation device that can include a separation tube or container that has a wall defining an internal volume into which a material can be placed is disclosed. The material can include a multi-component mixture or solution. A secondary tube or withdrawal cannula can be placed and/or moved within the tube to withdrawal a material form the tube.

Fixed chamber separator with adjustment withdrawal member

A buoy or float can be positioned within a separation container to assist in a physical separation of components of a whole material positioned in the separation container. The buoy can be positioned within the container to move from between and separation a first end and a second end of the container substantially unaffected by a portion of the whole material, including a clotted portion thereof. A first port can be provided near the first end of the container for introduction of the whole material and a second port can be provided near the second end of the container for removal of at least a portion of a separated material.

Apparatus and method for separating and concentrating fluids containing multiple components

An apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at various fractions in the apparatus. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient. Also selected fractions from the sample can be applied to a patient, either alone or as part of a mixture.

Methods for transfusing blood to a mammalian subject. The method includes obtaining a unit of blood, rejuvenating the blood with an enhancement composition, measuring 2,3-DPG concentration of the blood, and delivering the blood to a subject.

A bone marrow aspiration assembly including an outer cannula assembly, an inner cannula assembly, and a flexible seal. The outer cannula assembly includes an outer handle and an outer cannula defining a first passageway and including a plurality of first openings between a first end and a second end of the first passageway. The inner cannula assembly includes an inner handle and an inner cannula defining a second passageway and is configured to be received within the first passageway. The inner cannula includes a plurality of second openings between a first end and a second end of the second passageway. The flexible seal is mounted to the inner handle and positioned such that the seal contacts the outer cannula assembly when the inner cannula assembly is in cooperation with the outer cannula assembly to create a substantially airtight seal therebetween.

Bone marrow aspiration needle

A bone marrow aspiration assembly including an outer cannula and an inner cannula. The inner cannula is moved only radially about a longitudinal axis thereof with respect to the outer cannula to selectively align inner openings of only one of distal, intermediate, and proximal opening groups of the inner cannula with outer openings of only one of distal, intermediate, and proximal opening groups of the outer cannula to permit aspiration therethrough.

Growing community of inventors

Fort Wayne, IN, United States of America

Matthew D Landrigan