Lockheed Martin Corporation

Vanderbilt University

Matthew D Keller

Charles A Lemaire

Mark P Bendett

Anita Mahadevan-Jansen

Jonathon D Wells

Andrew Xing

James M Owen

Shuming Yuan

Isaac Pence

Constantine A Paras

Mark C Kelley

Lisa White

Elizabeth Kanter Bartz

John Phay

Bryan Joseph Norton

Robert W Royse

Nicole Gasparino

Jennifer Gray Whisenant

Jennifer Whisenant Amundson

Nicole Mathews

Brandon P Schmidt

Isaac J Pence

Constatine A Paras

In one aspect, the present invention relates to a process for intra-operatively providing anatomical guidance in endocrine surgery. In one embodiment, the process includes the steps of illuminating tissues in the neck area of a living subject with a beam of light having a predetermined wavelength, obtaining Raman data from light scattered from the illuminated tissues, finding Raman signatures corresponding to thyroid or parathyroid tissues from the obtained Raman data, and identifying the thyroid or parathyroid tissues from the corresponding Raman signatures.

Methods and systems for intra-operatively providing anatomical guidance in surgery

Intra-operative use of fluorescence spectroscopy and applications of same

The invention in one aspect relates to a method for discriminating soft biological tissues. The method includes illuminating soft biological tissues at at least one first spot with light; collecting Raman scattering light scattered from the soft biological tissues at at least second spot in response to illumination by the light, wherein the at least second spot is away from the at least one first spot so as to define a source-detection (S-D) offset distance therebetween; obtaining a spatially offset Raman spectrum from the collected light, wherein the spatially offset Raman spectrum is associated with a depth of the soft biological tissues at which the Raman light is scattered; identifying tissue signatures from the spatially offset Raman spectrum; and determining whether the soft biological tissues have a layered structure from the tissue signatures from the spectrum.

Spatially offset raman spectroscopy of layered soft tissues and applications of same

Method and apparatus for infrared-light nerve stimulation plus low-level light therapy (INS-plus-LLLT) that includes providing an infrared-light nerve stimulation plus low-level light therapy (INS-plus-LLLT) device; implanting the INS-plus-LLLT device in the animal; emitting a plurality of infrared laser-light nerve-stimulation signals from the INS-plus-LLLT device and directing the plurality of infrared laser-light nerve stimulation signals toward a neural tissue of the animal in order to trigger an action potential response in the neural tissue; and generating a plurality of low-level light therapy signals using the INS-plus-LLLT device and directing the low-level light therapy signals toward the neural tissue of the animal, wherein the low-level light therapy signals are configured to be efficacious for pain management in order to reduce an acute pain of the animal.

Apparatus and method for managing chronic pain with infrared and low-level light sources

The present invention in one aspect relates to a method for surgical margin evaluation of tissues during breast conserving therapy at a surgical site of interest. In one embodiment, the method comprises the steps of acquiring a plurality of spatially offset Raman spectra from the surgical site of interest, identifying tissue signatures from the plurality of spatially offset Raman spectra, and determining surgical margins of the surgical site from the identified tissue signatures.

Spatially offset Raman spectroscopy of layered soft tissues and applications of same

Method and apparatus for infrared-light nerve stimulation-plus-therapeutic-heat (INS-plus-TH) that includes providing a plurality of light sources; providing a plurality of thermally conductive extensions configured to transfer heat generated by the plurality of light sources away from the plurality of light sources; emitting a plurality of infrared-light nerve-stimulation signals toward neural tissue of an animal from the plurality of light sources, wherein the emitted infrared-light nerve-stimulation signals are configured to generate action potentials in the neural tissue, and wherein the emitting of the plurality of infrared-light nerve-stimulation signals includes generating heat; controlling the emitting of the plurality of infrared-light nerve-stimulation signals to generate action potentials in the neural tissue; and transferring the heat generated by the plurality of light sources during the emitting of the plurality of infrared-light nerve-stimulation signals away from the plurality of light sources and into surrounding tissue of the animal using the plurality of thermally conductive extensions.

Apparatus and method for managing chronic pain with infrared light sources and heat

Apparatus and method for making and using devices that generate optical signals, and optionally also electrical signals in combination with one or more such optical signals, to stimulate (i.e., trigger) and/or simulate a sensory-nerve signal in nerve and/or brain tissue of a living animal (e.g., a human), for example to treat nerve damage in the peripheral nervous system (PNS) or the central nervous system (CNS) and provide sensations to stimulate and/or simulate 'sensory' signals in nerves and/or brain tissue of a living animal (e.g., a human) to treat other sensory deficiencies (e.g., touch, feel, balance, visual, taste, or olfactory) and provide sensations related to those sensory deficiencies, and/or to stimulate (i.e., trigger) and/or simulate a motor-nerve signal in nerve and/or brain tissue of a living animal (e.g., a human), for example to control a muscle or a robotic prosthesis.

Nerve-penetrating apparatus and method for optical and/or electrical nerve stimulation of peripheral nerves

Optical bundle apparatus and method for optical and/or electrical nerve stimulation of peripheral nerves

Apparatus and method for triggering nerve-action potentials (NAPs) in each of a plurality of cochlear neurons in a cochlea of a person and in each one of a plurality of vestibular neurons in a vestibular organ of the person in order to provide auditory and balance sensations for the person, the method including generating a first plurality of light signals that stimulate a NAP in the selected cochlear neuron; delivering the first plurality of light signals to the selected cochlear neuron from within the cochlea; generating a second plurality of light signals that stimulate a NAP in the selected vestibular neuron; delivering the second plurality of light signals to the selected vestibular neuron from within the vestibular organ; and selectively controlling the first and second plurality of light signals to optically stimulate the selected cochlear and vestibular neuron in order to trigger NAPs of the selected cochlear and vestibular neuron.

Combined vestibular and cochlear implant and method

Apparatus and method for optical- or optical-and-electrical stimulation of e.g., auditory nerve pathways, for example spiral ganglion in the cochlea or neurons in the cochlear nerve. Several configurations for guiding and directing the optical stimulation are disclosed. Several configurations for guiding and directing the electrical field (used in some embodiments, for sensitization) in and through the destination tissue to which the optical stimulation is directed are disclosed. In some embodiments, and array of IR VCSELs emit stimulation light, in particular to tissue in the cochlea for restoring hearing. In some embodiments, an electrical signal is also applied in a manner that reduces the amount of light in a pulse that is otherwise needed to elicit a NAP. In some embodiments, a heat dissipater is used to spread the heat generated by operation of the lasers and their circuits, to avoid heat damage to the tissue.

Laser-based nerve stimulators for, E.G., hearing restoration in cochlear prostheses and method

Cuff apparatus and method for optical and/or electrical nerve stimulation of peripheral nerves

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Kirkland, WA, United States of America

Matthew D Keller