Dekalb Genetics Corporation

Pfizer Corporation

Other

Matthew Curtis Griffor

Paul S Chomet

Paul C Anderson

Alan L Kriz

Ye Che

Philip R Dormitzer

Thomas Richard Jones

Seungil Han

Xiayang Qiu

Xiaoyuan Sherry Chi

Laurent Oliver Chorro

Jennifer Anne Nicki

Xiaojie Yao

Yuhang Liu

Robert George Konrad Donald

Xinzhen Yang

Natalie Clare Silmon De Monerri

Kyle Paul Heim

This disclosure relates to the design ofmutated FimH polypeptides that result in improved biochemical properties and immunogenicity, compositions comprising such polypeptides, and uses thereof.

FimH mutants and uses thereof

The present invention relates to polypeptides and cytomegalovirus (CMV) antigens that include at least one introduced amino acid mutation relative to the amino acid sequence of the wild-type HCMV glycoprotein B (gB). In some embodiments, the polypeptide is stabilized in a conformation alternative to the gB postfusion conformation. Also disclosed are compositions including the polypeptides and uses thereof.

Human cytomegalovirus gB polypeptide

The present invention provides a method for conferring tolerance to an amino acid analog of tryptophan to a plant and/or altering the tryptophan content of a plant by introducing and expressing an isolated DNA segment encoding an anthranilate synthase in the cells of the plant. Transgenic plants transformed with an isolated DNA segment encoding an anthranilate synthase, as well as seeds and progeny derived from these plants, are also provided. The present invention also provides a cDNA sequence of an alpha and a beta subunit of a maize anthranilate synthase.

Anthranilate synthase gene and method for increasing tryptophan production

Anthranilate synthase gene and method of use thereof for conferring tryptophan overproduction

Anthranilate synthase gene and method of use thereof for conferring

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North Stonington, CT, United States of America

Matthew Curtis Griffor