Enanta Pharmaceuticals, Inc.

Matthew C Rhodes

Yat Sun Or

Xuechao Xing

Guoqiang Wang

Ruichao Shen

Yong He

Hui Cao

Wei Li

Jiajun Zhang

Xiaowen Peng

Xuri Gao

Joseph D Panarese

Samuel Bartlett

The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.

Spiropyrrolidine derived antiviral agents

The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, thereof: which inhibit picornavirus, norovirus or coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a virus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.

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Boston, MA, United States of America

Matthew C Rhodes