Theravance, Inc.

Biowest Therapeutics Inc.

Matthew B Nodwell

James Bradley Aggen

Edmund J Moran

Paul Ross Fatheree

Daniel D Long

Martin Sheringham Linsell

Daniel Marquess

S Derek Turner

Jason P Chinn

Michael Robert Leadbetter

John R Jacobsen

Timothy J Church

Sean Gary Trapp

William V Curran

Donald B Borders

Dale R Cameron

Qi Jia

Richard A Leese

Yuchen Chen

Vincent A Boyd

Paulo W M Sgarbi

Shirley A Wacowich-Sgarbi

Dominique Dugourd

This invention provides cephalosporin compounds and salts thereof. Such compounds are useful for preparing cross-linked glycopeptide-cephalosporin antibiotics.

Cephalosporin compounds

The present invention provides derivatives of lipopeptide antibiotics that display antimicrobial activity against microorganisms, methods and compounds for synthesizing such antimicrobial derivatives and analogues, and methods of using the compounds in a variety of contexts, including in the treatment and prevention of microbial infections.

Compositions of lipopeptide antibiotic derivatives and methods of use thereof

This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.

Cross-linked glycopeptide-cephalosporin antibiotics

The invention provides novel &#x3b2;adrenergic receptor agonist compounds of formula (I):  wherein R-Rand w have any of the values described in the specification. The invention also provides combinations of such compounds and other therapeutic agents, pharmaceutical compositions comprising such compounds and combinations, methods of using such compounds to treat diseases associated with &#x3b2;adrenergic receptor activity, and processes and intermediates useful for preparing such compounds.

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Cross-linked glycopeptide&#x2014;cephalosporin antibiotics

This invention provides cross-linked glycopeptide&#x2014;cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.

Aryl aniline &bgr;2 adrenergic receptor agonists

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Vancouver, Canada

Matthew B Nodwell