University of Utah Research Foundation

Matthew B Kraft

Anh P Truong

Dennie S Welch

Jonathan A Covel

Carina Cristina Sanchez

Gary E Keck

Wei Li

Yam Poudel

Described herein are tricyclic macrolactones. The macrolactones have a high binding affinity for PKC. The compounds described herein can be used in a number of therapeutic applications including cancer and Alzheimer's prevention and treatment. The compounds described herein can also treat memory loss. Also described herein are methods for producing macrolactones. The methods permit the high-yield synthesis of macrolactones in fewer steps and with a higher degree of substitution and specificity.

Bryostatin analogues and methods of making and using thereof

Growing community of inventors

Salt Lake City, UT, United States of America

Matthew B Kraft