National Institutes of Health, a Component of the US Dept. of Health & Human Services

University System of Maryland

Thomas Jefferson University

Matthew B Frieman

Lisa E Hensley

Matthias Johannes Schnell

Christoph Wirblich

Reed F Johnson

Christopher M Coleman

Peter B Jarhling

The present disclosure provides methods and compositions for inducing an immune response that confers dual protection against infections by either or both of a rabies virus and a coronavirus, and/or which can be used therapeutically for an existing infection with rabies virus and/or a coronavirus to treat at least one symptom thereof and/or to neutralize or clear the infecting agents. In particular, the present disclosure provides a recombinant rabies virus vector comprising a nucleotide sequence encoding at least one coronavirus immunogenic glycoprotein fragment, as well as pharmaceutical compositions comprising the vaccine vectors.

Multivalent vaccines for rabies virus and coronaviruses

The present invention provides methods for treating a coronavirus infection. For example, treatment may be effected by administering a neurotransmitter inhibitor, a signaling kinase inhibitor, an estrogen receptor inhibitor, a DNA metabolism inhibitor or an anti-parasitic agent. Also provided are methods for treating a coronavirus infection in which an anti-viral drug also is administered during any of the described methods.

Methods of treating coronavirus infection

Growing community of inventors

Baltimore, MD, United States of America

Matthew B Frieman