University of California

Other

Matthew B Francis

James A Holmes

Carolyn Ruth Bertozzi

Richard A Mathies

Erik Douglas

Amy Twite

Hiroaki Onoe

Shih-Chia Hsiao

Ravi Chandra

Nicholas Toriello

Richard Kwant

Meera Rao

Christian Bech Rosen

Troy Moore

Katherine J Mackenzie

Chawita Netirojjanakul

A silicon carbide transistor used as an ultraviolet light sensor. The light sensor is mounted inside a probe for detecting ultraviolet light generated by combustion inside an engine. The silicon carbide transistor generates a light voltage that is converted to a digital signal. The digital signal is used in a feedback loop for an engine control module for real time engine control in operating environments. The silicon carbide transistor is mounted inside a glow plug sized engine probe mounted in the cylinder head and the probe includes a quartz window allowing ultraviolet light access between the combustion chamber and the silicon carbide transistor so that the silicon carbide transistor can be mounted proximate the combustion chamber but behind the cooling jackets inside the engine head.

Integrated silicon carbide ultraviolet sensors and methods

A bipolar complementary metal oxide semiconductor three transistor pixel with P-type metal-oxide-semiconductor base discharge and N-type metal-oxide-semiconductor emitter blocking.

Bi CMOS pixel

Methods for preparing a protein conjugate having a defined number of conjugate groups are provided. The method includes: forming a mixture containing a macrocyclic matrix material and a plurality of proteins; eluting the proteins to obtain a first separated protein fraction and a second separated protein fraction, wherein substantially all of the proteins in the first separated protein fraction have the same number of handle moieties; contacting the handle moieties with a conversion reagent under conditions sufficient to convert the handle moieties in the first separated protein fraction to reactive moieties; and contacting the reactive moieties with a conjugation reagent under conditions sufficient to form a plurality of protein conjugates, wherein substantially all of the protein conjugates in the plurality have the same number of conjugate groups. Methods also include recovering enzymes and other proteins from mixtures for isolation and/or reuse of the enzymes and proteins.

Affinity-assisted protein modification and recycling

The present invention provides conjugates of DNA and cells by linking the DNA to a native functional group on the cell surface. The cells can be without cell walls or can have cell walls. The modified cells can be linked to a substrate surface and used in assay or bioreactors.

DNA-cell conjugates

A sulfonamide based rare earth element ion separation media and method of synthesis and use are provided. A bed or column of sulfonamide resin for separations can be prepared by exposing a sulfonate resin to chlorosulfonic acid to form a sulfonyl chloride resin; exposing the sulfonyl chloride resin to aqueous ammonia to form a sulfonamide resin; and then packing the sulfonamide resin into a separation column. Mixtures of lanthanide and other rare earth ions with very similar atomic radii and characteristics can be separated by flowing a mixture of lanthanide ions through a bed of sulfonamide resin followed by a mobile phase of an organic acid such as lactic acid to elute the separated rare earth element ions separated by the sulfonamide resin. Collected fractions of eluate can also be recycled through the sulfonamide media.

Sulfonamide-based separation media for rare earth element separations

Provided herein are methods for enhancing enzymatic activity using certain polymers that may be optionally attached to an enzyme. The polymers may be thermally-responsive polymers, including poly N-isopropylacrylamide or poly N-isopropylmethacrylamide. The polymer may also be a copolymer with at least two different monomer residues. The monomer residues may have a structure of formula (I): wherein R, Rand Rare as described herein. Examples of such monomer residues may include N-isopropylacrylamide (NIPAm) or N-isopropylmethacrylamide (NIPMa). The polymer may include additional monomer residues, such as aminooxy-bearing methacrylamide monomer residues that can be modified to vary the lower critical solution temperature (LCST) of the polymer.

Polymer enhancement of enzymatic activity

The present disclosure provides modified Fc domains having one or more attachment moieties for attaching a heterologous functional moiety; and methods of generating the modified Fc domains. The present disclosure provides Fc conjugates; and methods of making the conjugates. The Fc conjugates are useful in various methods, which are also provided.

Growing community of inventors

Berkeley, CA, United States of America

Matthew B Francis