Pfizer Corporation

Other

Agouron Pharmaceuticals, Inc.

Matthew Arnold Marx

Jinshan Michael Chen

Michael Luzzio

Susan LaGreca

Michael John Munchhof

Bingwei Vera Yang

Susan D La Greca

Matthew David Wessel

Susan Beth Sobolov-Jaynes

Christopher Lowell Autry

Joel Thomas Arcari

The invention relates to compounds of the formula 1 or a pharmaceutically acceptable salt, prodrug, solvate or hydrate thereof, wherein L, R, R, Rand Rare as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating abnormal cell growth, such as cancer in a mammal by administering the compounds of formula 1.

Substituted pyrrolo[2,3-d]pyrimidine derivatives useful in cancer treatment

The invention relates to compounds of the formula 1 or a pharmaceutically acceptable salt, prodrug or hydrates thereof, wherein X, L, R, R, Rand Rare as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula 1.

Substituted pyrrolopyrimidines useful in the treatment of cancer

The present inventiondiscloses a workout benchhaving a plurality of incline adjustments and stanchions with means for receiving dumbbell weights. The dumbbell stanchion comprises a tubular structurehaving a base portionextending transversely to its distal ends, forming vertical stanchions. The vertical stanchionscomprise a weight rest stanchionwith weight restthat is slidably adjustable having apertureslinearly arranged in conjunction with a locking pinprovided on the main vertical stanchions. The bench comprises two cushionsfixedly attached to individual frame structureseach hingedlyconnected at the center. At the other distal end of the cushion frameare collapsible leg supportsthat fold up allowing the cushionsto rest on the floor's surface at an angle from the pivot point. Also disclosed are internal extendable bracesfor raising the cushions

Dumbbell workbench

The invention relates to compounds of the formula 1 or a pharmaceutically acceptable salt, prodrug or hydrates thereof, wherein Q, A, L, R, Rand Rare as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula 1.

Pyrrolopyrimidine derivatives

The invention relates to compounds of the formulas 1 and 2and to prodrugs thereof, pharmaceutically acceptable salts or solvates of said compounds or said prodrugs, wherein X, Rand Rare as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formulas 1 and 2 and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formulas 1 and 2.

Bicyclic pyrimidine and pyrimidine derivatives useful as anticancer agents

The invention relates to compounds of the formula 1or a pharmaceutically acceptable salt and to pharmaceutically acceptable salts and hydrates thereof, wherein X, Y, R, Rand Rare as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula 1.

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Waterford, CT, United States of America

Matthew Arnold Marx