Wisconsin Alumni Research Foundation

Matthew Allen

Ronald Thaddeus Raines

Laura Lee Kiessling

Gurindar Singh Sohi

A method of dynamic parallelization in a multi-processor identifies potentially independent computational operations, such as functions and methods, with a serializer that assigns a computational operation to a serialization set and a processor based on assessment of the data that the computational operation will be accessing upon execution.

Assigning different serialization identifier to operations on different data set for execution in respective processor in multi-processor system

Polymeric chelating agents and metal chelates, particularly those of lanthanide metals and more specifically those of Gd(III), useful as contrast agents in magnetic resonance imaging (MRI) for therapeutic and diagnostic applications as well as clinical and biomedical research applications. The polymeric chelates are generated using ring-opening metathesis polymerization (ROMP). Polymers can have multiple sites for functionalization allowing for the synthesis of multimodal and targeted contrast agents. Hydroxypyridonate (HOPO)-based chelating moieties are integrated into a ROMP-derived polymer. More specifically, the HOPO-based chelating moiety is integrated into a benzonorbornadiene unit that constitutes the backbone of the polymer. The ROMP-derived polymer chelators can comprise multiple metal ions, particularly Gd(III) ions, in polymers of varying lengths to provide a series of agents with controlled relaxivites. Polymer chelates include those that are water-soluble.

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Madison, WI, United States of America

Matthew Allen