Pfizer Corporation

Evotec Ag

Terran Biosciences, Inc.

Reservoir Neuroscience, Inc.

Renovis, Inc.

Pfizer Global Research and Development

Matthew Alexander James Duncton

Michael G Kelly

Kentaro Futatsugi

Zhan Wang

John Kincaid

Koji Ando

Donogh John Roger O'Mahony

Zhi-Liang Wei

Andrew Antony Calabrese

Matthew Cox

Satoshi Nagayama

Misato Hirano

Maria De Los Angeles Estiarte-Martinez

Satochi Nagayama

Andrew Anthony Calabrese

Sam Clark

Aaron R Friedman

Steven Howard Olson

Vladimir V Senatorov, Jr

Tadashi Kawashima

Yuji Shishido

Hirotaka Tanaka

Donogh O'MAHONY

Maria De Los Angeles Estiarte-Marinez

Yuji Shisido

Donogh John Roger O'MAHONY

Described herein are compounds that are EP2 antagonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of diseases or conditions associated with EP2 activity.

EP2 antagonist compounds

Described herein are compounds that are derivatives of DMT or 5-MeO-DMT and can be metabolically converted to N,N-dimethyltryptamine or analogs thereof upon administration to a subject. In certain embodiments, the compounds described herein are useful for the treatment of conditions associated with a neurological disease.

N,N-dimethyltryptamine and related psychedelics and uses thereof

Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same

This invention provides a compound of the formula  These compounds are useful for the treatment of disease conditions caused by overactivation of the VR1 receptor such as pain, or the like in mammal. This invention also provides a pharmaceutical composition comprising the above compound.

Substituted bicyclocarboxyamide compounds

Growing community of inventors

San Bruno, CA, United States of America

Matthew Alexander James Duncton