Vernalis Research Limited

Matthew Alexander James Duncton

David Reginald Adams

Jonathan Richard Anthony Roffey

Jonathan Mark Bentley

Suneel Gaur

Richard John Hamlyn

Jon Mark Bentley

James Davidson

Richard Hugh Phillip Porter

Howard Langham Mansell

James Edward Paul Davidson

Claire Elizabeth Dawson

Nathaniel Monck

Ian Anthony Cliffe

Robert Mark Pratt

Ashley Roger George

David Bebbington

Michael John Bickerdike

Chemical compounds of formula (I): and pharmaceutically acceptable salts and addition compounds and prodrugs thereof are useful in therapy, particularly for the treatment of disorders of the central nervous system; damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders; diabetes inspidus, and sleep apnea.

Pirazino(aza)indole derivatives

Pirazino indole derivatives

A chemical compound of formula (I), wherein n is 1, 2 or 3; R and R are independently selected from hydrogen and alkyl; R is alkyl; R to R are independently selected from hydrogen, halogen, hydroxy, alkyl, aryl, alkoxy, aryloxy, alkylthio, arylthio, alkylsulfoxyl, alkylsulfonyl, arylsulfoxyl, arylsulfonyl, amino, monoalkylamino, dialkylamino, nitro, cyano, carboxaldehyde, alkylcarbonyl, arylcarbonyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, alkoxycarbonylamino, aminocarbonyloxy, monoalkylaminocarbonyloxy, dialkylaminocarbonyloxy, monoalkylaminocarbonylamino and dialkylaminocarbonylamino, or R and R together form a carbocyclic or heterocyclic ring, and pharmaceutically acceptable salts and prodrugs thereof, and the use thereof in therapy, particularly for the treatment of disorders of the central nervous system; damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders, diabetes insipidus, and sleep apnea, and particularly for the treatment of obesity

Pyrroloindoles, pyridoindoles and azepinoindoles as 5-ht2c agonists

Indoline derivatives as 5-HT2B and or 5-HTC receptor ligands

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Wokingham, United Kingdom

Matthew Alexander James Duncton