Amtek Research International LLC

Ore-medix LLC

Matthew Alan Warren

Richard W Pekala

James E Emanuel

Weston J Wood

Chi Thuong-Le La

Cory S Rogers

Scott Thomas Sackinger

Don Spitz

Halogen-free, microporous polyolefin membranes are disclosed herein. The halogen-free, microporous polyolefin membranes can be manufactured using an environmentally friendly manufacturing process that includes extrusion of polymer-plasticizer mixtures followed by sheet formation and extraction of the plasticizer with a halogen-free solvent. The halogen-free solvent has a flashpoint greater than about 23° C. and an initial boiling point at least about 50° C. lower than the flashpoint of the plasticizer. The process can further be a closed loop process in which the halogen-free solvent can be reused.

Microporous polyolefin membranes from bespoke solvents

A polymer fiber sheet exhibits high porosity and good tensile properties in both 'wet' and 'dry' states. A fiber modifying agent is incorporated into a polymer extrusion and fiber formation process to produce a highly porous polymer fiber sheet that is instantaneously wettable by an aqueous medium. The fiber modifying agent functions as either one or both (1) a plasticizer that reduces the polymer extrudate melt viscosity and allows the formation of fine fibers during processing and (2) a surface modifying agent that promotes the instantaneous and sustainable wettability of individual polymer fibers and a porous fiber sheet formed from them. The polymer fiber sheet maintains its wettability even after repeated washing and drying cycles. The resultant fiber sheet can be densified and embossed to provide a desired thickness and porosity, while at the same time longitudinal ribs with desired pattern can also be formed on the fiber sheet.

Instantaneously wettable polymer fiber sheet

A conformable structured therapeutic dressing () has maximum available surface area () of a therapeutic agent () to stimulate therapeutic response in wounded tissue of a mammalian subject. In preferred embodiments, the therapeutic agent includes a procoagulant to quickly arrest bleeding and prevent life-threatening blood loss. The wound dressing exhibits a structured adsorbent () that maximizes available surface area of a functional filler (). This is achieved with a minimal amount of binder () and small, porous particles of the functional filler. Minimizing the binder maximizes the amount of functional filler and reduces the chance that the binder will block access to the surface area of the functional filler. Porous particles have a large internal surface area. Structured adsorbents with higher surface areas, higher inter- and intra-fiber porosities, and low internal mass transfer resistances produce higher rates of mass transfer of an adsorbent onto the functional filler.

Conformable structured therapeutic dressing

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Salem, OR, United States of America

Matthew Alan Warren