Case Western Reserve University

Matthew A Schiefer

Dustin J Tyler

Daniel Brian Tan

Ronald J Triolo

Warren M Grill

Matthew Stone

Lee Fisher

Michael E Miller

Natalie Brill

Michael Miller

One aspect of the present disclosure relates to a system that can modulate the intensity of a neural stimulation signal over time. A pulse generator can be configured to generate a stimulation signal for application to neural tissue of an individual and modulate a parameter related to intensity of a pattern of pulses of the stimulation signal over time. An electrode can be coupled to the pulse generator and configured to apply the stimulation signal to the neural tissue. A population of axons in the neural tissue can be recruited with each pulse of the stimulation signal.

Patterned stimulation intensity for neural stimulation

An implantable cuff includes an elastic collar, at least one conductive segment disposed on or within the elastic collar, and at least one conductor in electrical communication with the at least one conductive segment. The elastic collar defines an internal opening configured to receive an internal body tissue. At least a portion of the elastic collar includes a stiffening region having a stiffness greater than a second region of the elastic collar. The at least one conductor is configured to operably mate with an apparatus capable of delivering electrical stimulation to, and/or recording an electrical activity of, the internal body tissue.

Implantable cuff and method for functional electrical stimulation and monitoring

The present invention generally relates to patterned intensity modulation of neural tissue. Certain embodiments provide a method of treating medical conditions by providing an electrode and modulating stimulation parameters delivered by the electrode. The stimulation parameters that are modulated relate to stimulation intensity and are varied according to a stimulation input parameter or time. The stimulation input parameter can be a choice of an individual waveform (i.e. &#x3a8; or psi), which may be varied for each pulse.

Methods of treating medical conditions by population based encoding of neural information

A method for electrically stimulating a retina of an eye to induce visual perception includes placing an electrode adjacent a retinal ganglion cell (RGC) layer and selectively applying a biphasic asymmetrical waveform (BAW) to a portion of the axon. The BAW includes a pre-pulse phase and a stimulation-pulse phase. The pre-pulse phase has a first polarity, a first amplitude, and a first duration. The first amplitude and the first duration together define a pre-pulse charge having a first magnitude. The stimulation-pulse phase has a second polarity opposite the first polarity, a second amplitude, and a second duration less than the first duration. The second amplitude and the second duration together define a stimulation charge having a second magnitude. Application of the pre-pulse phase and the stimulation-pulse phase effects a change in excitability of the at least one ganglion cell and induces visual perception, respectively.

Growing community of inventors

University Heights, OH, United States of America

Matthew A Schiefer