Columbia University

Matteo Palma

James Hone

Samuel Jonas Wind

Ruben L Gonzalez, Jr

Alexander Alexeevich Godarenko

Colin Kinz-Thompson

Daniel Alexandre Chenet

The disclosed subject matter provides a nanoaperture having a bottom surface and a side wall comprising gold. A surface of the side wall is passivated with a first functional molecule comprising polyethylene glycol. The bottom surface of the nanoaperture can be functionalized with at least one second molecule comprising polyethylene glycol, for example, a silane-PEG molecule. The second molecule can further include a moiety, such as biotin, which is capable of binding a target biomolecule, which in turn can bind to a biomolecule of interest for single molecule fluorescence imaging analysis. Fabrication techniques of the nanoaperture are also provided.

Growing community of inventors

New York, NY, United States of America

Matteo Palma