F.i.s. Fabbrica Italiana Sintetici S.p.a.

Matteo De Poli

Pierluigi Padovan

Paolo Stabile

Angelo Restelli

Nicolas Tesson

Jordi De Mier Vinue

Stefano Fogal

Jordi De Mier Vinué

The present invention relates to a process for the preparation of Droxidopa by means of an improved enzymatic reduction of a compound of formula (II): (II), wherein R, Ris independent hydrogen, acetyl, Ris hydrogen, a C1-C4 linear or branched alkyl group and Ris hydrogen or an amine protecting group. 

Enzymatic process for the preparation of Droxidopa

Object of the present invention is a highly stable crystalline form of Eltrombopag (ETP) monoethanolamine salt, named Form D1, having the highest thermodynamically stability with excellent non-hygroscopicity, and particularly well suitable for pharmaceutical purposes, with related process.

Highly stable crystalline Eltrombopag monoethanolamine salt form D1

Object of the present invention is a better crystalline form of Eltrombopag (ETP) monoethanolamine salt, named Form D, stable, suitable for pharmaceutical purposes, and with the highest solubility in water and excellent non-hygroscopicity, then the related process and intermediates thereof.

Crystalline Eltrombopag monoethanolamine salt form D

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Matteo De Poli