Farmabios S.p.a.

Matteo Curti

Claudio Gianluca Pozzoli

Valentina Canevari

Marco Brusasca

Lorenzo Menna

A method for the purification and preparation of melphalan that allows to obtain melphalan with purity higher than 99.5% is described.

Process for the purification of melphalan

A process for the preparation of nucleosides, derivatives and analogues thereof by coupling reaction of a protected suitable nitrogeneous purine or pyrimidine base, a derivative or analogue thereof and a protected suitable sugar in the presence of SnClcomprising the removal of SnCl4 by adding DMSO directly into the reaction mixture is described. Preferably said process is used for the preparation of antiviral and antitumor agents having a nucleoside or nucleoside-like structure, still more preferably for the preparation of azacytidine, decitabine, chlorfarabine, cladribine, mizoribine. A residual tin content lower than 300 ppm is obtained with said process.

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Gropello Cairoli, Italy

Matteo Curti