Janssen Pharmaceutica Nv

Theravance Biopharma R&d Ip, LLC

Noramco Gmbh

Matteo Conza

Susanne Lochner

Stefan Horns

Magali B Hickey

Vit Lellek

Diego Broggini

Zhaobin Wang

Lucie Lovelle

Guangrong Tang

Oliver Flögel

Ioannis Nicolaos Houpis

Xiaojun Huang

Cyril Ben Haim

Hartmut B Zinser

Dimitar Filipov

Philip James Pye

Anja Huste

Norbert Kraut

Stephen Roseblade

Christian Pater

Bjorn Gielen

Philip Pye

The present disclosure provides processes for preparing a crystalline form of 3-((1R,3s,5S)-3-((7-((5-methyl-1H-pyrazol-3-yl)amino)-1,6-naphthyridin-5-yl)amino)-8-azabicyclo[3.2.1]octan-8-yl)propanenitrile and related intermediate compounds.

Processes for preparing a pan-JAK inhibitor and related intermediate compounds

The present invention relates to certain intermediates useful in the preparation of certain benzoimidazol-2-yl pyrimidines and processes for preparing them. In particular, the present invention relates to various 2-[3-(1-methyl-piperidin-4-yl)-propylamino]-pyrimidine-5-carboxylic acids and amides as useful intermediates in the preparation of compounds including 

Substituted 2-[3-(1-methyl-piperidin-4-yl)-propylamino]-pyrimidine-5-carboxylic acids and amides and methods of making the same

The present invention is directed to a process for the preparation of opioid compounds such as buprenorphine, naltrexone, naloxone, nalbuphone, nalbuphine, and the like.

Process for the preparation of opioid compounds

Benzoimidazol-2-yl pyrimidines, purification methods for the same, and pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by Hreceptor activity, including allergy, asthma, autoimmune diseases, and pruritus.

[object Object]

Disclosed is a process for the preparation of the following compounds: where R, Rand Rhave the definitions in the description, as well as a process to prepare other intermediates that may be useful to synthesize downstream products, especially compounds that are useful as medicaments, for instance Bruton's tyrosine kinase (Btk) inhibitors such as ibrutinib. Also disclosed are other processes, other intermediates and compounds per se.

Processes and intermediates for preparing a medicament

Benzoimidazol-2-yl pyrimidine modulators of the histamine h4 receptor

Growing community of inventors

Thayngen, Switzerland

Matteo Conza