Other

Quiatech Ab

Olink Ab

Telefonaktiebolaget Lm Ericsson (publ)

Mats Nilsson

Ulf Landegren

Marek Kwiatkowski

Mats Gullberg

Peter Svedlindh

Klas Gunnarsson

Jenny Göransson

Maria Strçmme

Mattias Strömberg

A novel detection or quantifying method for biological entities or molecules such as, but not limited to, DNA, microorganisms and pathogens, proteins and antibodies, that by themselves are target molecules or from which target molecules are extracted, comprises the steps of i) forming target molecule-dependent volume-amplified entities, ii) allowing magnetic nanoparticles to bind to said volume-amplified entities, and iii) measuring changes in dynamic magnetic response of the magnetic nanoparticles caused by the increase in hydrodynamic volume of said magnetic nanoparticles.

Magnetic detection of small entities

A nucleic acid amplification method, and probes for use within the method are described.

Nucleic acid amplification method

A method of preparing an immobilized oligonucleotide having a free 3&prime;-end comprises the steps of: i) preparing an oligonucleotide attached in a first position to a solid support via its 3&prime;-end and having a free 5&prime;-end; ii) binding said oligonucleotide in a second position remote from the 3&prime;-end to the solid support; and iii) selectively releasing the 3&prime;-end of the oligonucleotide from the solid support to obta the oligonucleotide attached to the support in said second position in a reversed orientation with a free 3&prime;-end.

Synthesis of oligonucleotides

The present invention relates to a support system for solid phase synthesis of oligomers, such as oligonucleotides, wherein the starting compound is bound to the support via a disiloxyl linkage. Furthermore, the invention relates to a method for synthesis of oligonucleotides on a solid support. The support system comprises a stable disiloxyl linkage providing high nucleoside loadings to the support and the method allows convenient non-laborious oligomer synthesis.

Solid phase synthesis

The present invention relates to a support system for the solid phase synthesis of oligomers, such as oligonucleotide, wherein the starting compound is bound to the support via a disiloxyl linkage. Furthermore, the invention relates to a method for synthesis of oligonucleotides on a solid support. The support system comprises a stable disiloxyl linkage providing high nucleoside loadings to the support and the method allows convenient non-laborious oligomer synthesis.

A method of preparing an immobilized oligonucleotide having a free 3&prime;-end comprises the steps of: i) preparing an oligonucleotide attached in a first position to a solid support via its 3&prime;-end and having a free 5&prime;-end; ii) binding said oligonucleotide in a second position remote from the 3&prime;-end to the solid support; and iii) selectively releasing the 3&prime;-end of the oligonucleotide from the solid support to obtain the oligonucleotide attached to the support in said second position in a reversed orientation with a free 3&prime;-end.

A non-geostationary satellite communication system comprises a cellular system controller, a satellite system controller, and a management controller. The cellular system controller assigns each mobile station in the cellular system to a specific region and creates a record of such assignment, wherein each mobile station periodically updates its location within the system. The satellite system controller tracks the position and motion of the satellite and assigns and records the assignment of terrestrial regions, i.e., radio resources, to each satellite, and periodically hands off coverage of one region from one satellite to another. The management controller maps the region assignment records of the mobile stations with the satellite assignment records of the regions so as to perform mobility functions, handover, and location management due to the motion of the satellites and the mobile stations.

Growing community of inventors

Stockholm, Sweden

Mats Nilsson