Cytiva Sweden Ab

Ge Healthcare Bio-sciences Ab

Ge Healthcare Bioprocess R&d Ab

Cytiva Bioprocess R&d Ab

Mats Lundkvist

Johan Blomberg

Bjorn A Johansson

Tim Francois

Andreas Marcstrom

Klaus Gebauer

Daniel Salomonsson

Hanno Ehring

David Carl Martin Bergman

Jan Kranse

Bjorn Markus Olovsson

Tomas Yngve Agren

Dan Hermansson

Andreas Torbjorn Lundin

Olle Bjernulf

David Bergman

Klas Marteleur

David Gronowitz

Stefan Dargy

Karl Axel Jakob Liderfelt

Robert Magnusson

Tuomo Valtteri Frigard

Peter Arne Reffner

Helena Nordvarg

Sebastian Skoglund

Erik Nilsson

Andreas MARCSTRÖM

Disclosed are chromatography systems employing a releasable couplingfor holding a fluid tubing to a spigot, the coupling comprising: a cylindrical inner componentfor accepting a fluid tubing, said inner component including a resiliently deflectable portionarranged to urge an outer surface of the tubing toward a spigot; and a cylindrical collarhaving and internal through-aperturefor slideably accepting the inner component, the aperture and resilient portion having complementary surface formations which in a first position of the collar mounted to the inner component provide for said resilient deflection in use, and which in a second different position do not cause said deflection, the coupling being characterized in that the collar comprises a collar flangeextending outwardly away from the aperture of a size allowing manual manipulation of the collar between the first and second positions. Chromatography systems employing said couplings is disclosed also.

Chromatography system and couplings therefor

Disclosed is a chromatographic separation column assembly () comprising a column cylinder () having a cylinder wall () including an inner wall surface () partially defining a column volume (), and a column component () insertable into to the cylinder (), wherein at least an edge region () of the column component is intended to be in contact or adjacent a part of the inner wall surface () in use, the edge region and the contacting or adjacent part of inner wall surface each being formed from a compatible heat fusible material or materials, and wherein at least the cylinder wall in the area of the contacting or adjacent part of the inner wall is formed from a material which allows transmission of the light energy needed to cause said fusing of the adapter plate edge region to the inner wall surface.

Chromatography column and method of assembling the same

A multiple cavity reciprocating positive displacement pump comprising plural pump cavities each including at least one pair of one-way valves the at least one pair including an inlet valve and an outlet valve, the pump being characterised in that respective inlet valves are in fluid communication with a common inlet and respective outlet valves are in fluid communication with a common outlet. The multiple cavities may include diaphragm arranged in a radial configuration for more uniform pressure output.

Multiple cavity reciprocating positive displacement fluid pump

Automated fluid handling system comprising a housing and two or more fluid handling units arranged as interchangeable modular components with an external fluidics section and an internal non fluidics section, and wherein the housing comprises a liquid handling panel with two or more of component positions for receiving said interchangeable modular components such that the external fluidics section is separated from the non fluidics section by the liquid handling panel.

Automated fluid handling system

The invention relates to an optical flow cell comprising a housing forming an enclosed and elongated fluid channel arranged along a first axis, an inlet arranged to connect a first outer surface area of the housing to a first end of the fluid channel and an outlet arranged to connect a second outer surface area to a second end of the fluid channel, a first light guide and a second light guide concentrically arranged along a second axis and on opposite side walls of the fluid channel. The invention further relates to a corresponding method to produce an optical flow cell.

Optical flow cell

Disclosed is a modular bio-processing unit () comprising: a housing () having one or more internal fluid paths (), the housing having at least one inlet and at least one outlet (), each in fluid communication with the fluid path or one or more of the fluid paths; one or more sensor elements () operatively associated with the or each path, said sensor(s) elements including elements of one or more of: a flow sensor, a flow rate sensor, a conductivity sensor, a pressure sensor, a pH sensor, and a light absorbance sensor such as a UV spectroscopic concentration sensor; one or more fluid flow inducing components () operatively associated with the or each fluid path; and plural valves () for preventing or reducing flow in the or each path, the housing, inlet(s), outlet(s), flow inducing component(s) and valve(s) being arranged to operate together as a bio-processing unit within or substantially within the housing.

Modular bio-processing unit and a bio-processing system employing plural units

A multiple cavity reciprocating positive displacement pump () comprises a plurality of pump cavities (), each pump cavity () including at least an inlet valve () and an outlet valve (), wherein respective inlet valves () are in fluid communication with a common inlet () and respective outlet valves () are in fluid communication with a common outlet (), and wherein the pump cavities () are arranged about a pump axis (AR) and around said common inlet () and said common outlet ().

Pumps

Disclosed is a fraction collector for dispensing liquids into plural receptacles (P,P) arranged in a two dimensional array. The fraction collector comprises a table () for supporting said receptacles, and an arm supported above the table, in tum supporting a liquid dispenser (), the fraction collector arm is rotatable about an arm axis (C) and the liquid dispenser is movable along the arm on a carriage(). Thereby, the dispenser is low cost and is repositionable simply above the receptacles as a result of said rotation and as a result of said movement along the arm, without occupying too much laboratory bench space.

Liquid fraction collector for liquid chromatography system

Disclosed are chromatography systems employing a releasable coupling () for holding a fluid tubing to a spigot, the coupling comprising: a cylindrical inner component () for accepting a fluid tubing (), said inner component including a resiliently deflectable portion () arranged to urge an outer surface of the tubing toward a spigot; and a cylindrical collar () having and internal through-aperture () for slideably accepting the inner component, the aperture and resilient portion having complementary surface formations which in a first position of the collar mounted to the inner component provide for said resilient deflection in use, and which in a second different position do not cause said deflection, the coupling being characterized in that the collar comprises a collar flange () extending outwardly away from the aperture of a size allowing manual manipulation of the collar between the first and second positions. Chromatography systems employing said couplings is disclosed also.

A fluid distributor unit comprising a channel system where one or more inlet channels (2) starting on an inlet side (3) of the distributor unit branch out successively into several channels (6) ending on the other side of the distributor unit, called the outlet side (4), characterised in that said distributor unit is provided in one single body (1) by free form fabrication.

Fluid distributor unit

Disclosed is a fraction collector for dispensing liquids into plural receptacles (P,P) arranged in a two dimensional array. The fraction collector comprises a table () for supporting said receptacles, and an arm supported above the table, in turn supporting a liquid dispenser (), the fraction collector arm is rotatable about an arm axis (C) and the liquid dispenser is movable along the arm on a carriage(FIG.). Thereby, the dispenser is low cost and is repositionable simply above the receptacles as a result of said rotation and as a result of said movement along the arm, without occupying too much laboratory bench space.

Disclosed is an optical flow cell (') comprising: a housing () forming; an enclosed and elongated fluid channel () arranged along a first axis (); a first light guide () and a second light guide () generally concentrically arranged along a second axis () and on opposite side walls of the fluid channel, said first and second light guides having ends () removed in situ to provide a sensing gap (d).

Disclosed is a chromatography column cylinder () formed from a polymer composite comprising an outer layer () and inner layer () intended to be in direct contact with the intended contents of the cylinder in a volume (), wherein the outer layer supports the inner layer, for example when there is negative pressure in the volume (). In one embodiment, one of said layers is molded directly onto a surface of the other layer such that there is no gap between the two layers. Disclosed also is a method for forming a chromatography column cylinder.

Growing community of inventors

Uppsala, Sweden

Mats Lundkvist