Biotage Ab

Vicore Pharma Ab

Personal Chemistry I Uppsala Ab

Labwell Ab

Mats Larhed

Anders Rudolf Hallberg

Nils-Fredrik Kaiser

Mathias Alterman

Bengt Ohlsson

Tomas Fex

Ulf Bremberg

Christina Moberg

Gunnar Lindeberg

Yiqian Wan

Nadia Nasser Petersen

Hallberg Anders

There is provided pharmaceutical compounds of formula I, wherein R, R, R, R, R, R, Y, Y, Y, X and Z have meanings given in the description, which compounds are useful in the treatment of autoimmune and/or fibrotic diseases, including interstitial lung diseases, such as idiopathic pulmonary fibrosis and sarcoidosis.

Selective angiotensin II compounds

The present invention is drawn to a method of performing a one-pot organic reactions including carbon monoxide as reactant, without the use of an external CO gas source, wherein a reaction mixture containing a solid or liquid CO releasing compound, a non-metal substrate and a metal catalyst is exposed to an energy source to release carbon monoxide from the CO releasing compound and wherein carbon atoms of the released carbon monoxide form a bond with the non-metal substrate compound. The present invention is further drawn to a method of preparing chemical libraries and a kit for organic reactions.

Organic reactions with CO generating materials

The present invention is draw to microwave heating of a transition metal-catalysed organic reaction, in which a catalyst complex between a transition metal and an auxiliary ligand or ligands, the ligand being asymmetric or symmetric, monodentate or bidentate, results in highly chemoselective, regioselective, and stereoselective allylic substitution reactions. Molybdenum or palladium complexes form suitable catalytic systems with a plethora of ligands in a variety of solvents for such microwave facilitated nucleophilic substitution reactions.

Microwave facilitated allyllic substitution

Method for organic reactions

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Uppsala, Sweden

Mats Larhed