Cline Scientific Ab

Vitroprobe Analytics Ab

Hulander, Mats

Sundell, Gustav

Andersson, Martin

Mats Hulander

Hans Elwing

Anders Lundgren

Mattias Berglin

Martin Andersson

Gustav Sundell

The present invention relates to a method for determining the three dimensional structure of biomolecules, such as proteins, protein fragments, and peptides. The biomolecule is encapsulated in an amorphous silica matrix, from which a needle specimen is prepared. Atom probe tomography is then used to analyze the needle specimen and the data is used to reconstruct the three dimensional structure of the biomolecule. The present invention greatly facilitates determination of the three dimensional structure of biomolecules.

Method for analyzing the 3D structure of biomolecules

The present invention regards nano surfaces and particularly a gradient based nano surface. According to embodiments of the invention a surface bound gradient is created by distributed nanoparticles along a plane surface. This procedure greatly reduces the number of prepared surfaces needed, as well as the methodological error of analysis of adsorption and adhesion phenomena.

Method for preparing a surface with a controlled coverage of nanograde particles

Growing community of inventors

Göteborg, Sweden

Mats Hulander