Genecode As

Baltic Technology Development, Ltd.

Ou Raidenil

Mati Karelson

Mart Saarma

Mehis Pilv

Maxim Bespalov

Neinar Seli

Disclosed are compounds and methods for treating neurological and other disorders by administering to a subject in need thereof an effective amount of a compound having binding and/or modulation specificity for GFR&#x3b1; receptor molecules, which can be mimetics of glial-derived neurotrophic factor (GDNF) family ligands (GFLs), GFR&#x3b1;/RET signaling pathway agonists, and/or direct RET agonists (activators).

Methods of facilitating neural cell survival using GDNF family ligand (GFL) mimetics or RET signaling pathway activators

The present invention provides compounds having a chelating moiety and an oligonucleotide sequence wherein the oligonucleotide includes one or more modified nucleobases, such as hydroxynucleobases. The disclosed compounds are suitable for antisense therapy. The chelating moiety can be complexed to an ion of a lanthanide metal. These compounds are efficient translation inhibitors of nucleic acids and have increased binding affinity for target nucleic acids. The invention also includes compositions and methods of using these compositions as antisense therapy.

Antisense agents combining strongly bound base-modified oligonucleotide and artificial nuclease

The present invention discloses composite materials for distant laser sensing in the infrared spectral region. The composites are disclosed to consist of the conductive polymer, the infrared active compound and the thermoplastic matrix polymer.

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Vahi, Estonia

Mati Karelson