Centre National De La Recherche Scientifique

Rhodia Operations

Les Laboratoires Servier

Universitë De Bordeaux

Institut Polytechnique De Bordeaux

National Institute of Health and Medical Research

Sorbonne Université

Bostik Sa

Université Paris-Saclay

Centre National De La Recherche Scientifique-Cnrs

Bordeaux Inp

Mathieu Pucheault

Olivier Guerret

Guillaume Michaud

Olivier Back

Laurent Garel

Stéphane Fouquay

Lucile Vaysse-Ludot

Frédéric Simon

Michel Vaultier

Alexandre Le Flohic

Boris Colin

Flavie Sarrazin

Thomas Kaminski

Loic Guillonneau

Kevin Olivon

Virginie Liautard

Olivier Dellis

Camille Le Guilcher

The present invention relates to a process for preparing a mixture M1 of enol phosphate isomers devoid of (E,E) isomer and comprising at least 98% of (E,Z) isomer, at least 0.1% of (Z,Z) isomer and at least 0.1% of (Z,E) isomer, comprising bringing a mixture of isomers of said enol phosphate comprising a detectable amount of (E,E) isomer into contact with a hydrolysable dienophile in an organic solvent, followed by base hydrolysis of the medium obtained and elimination of the adduct formed, in order to obtain the mixture M1 devoid of (E,E) isomer.

Composition of 7,9-dodecadienyl-1-acetate isomers and process for production thereof

A process for preparing an aromatic compound or compounds where at least one mandelic group &#x2014;CHOH&#x2014;COOH is described, comprising a reaction for condensation of at least one aromatic compound with glyoxylic acid or derivatives thereof, wherein said condensation reaction is carried out substantially in the absence of any acid or any base added to the reaction medium. The condensation reaction is followed by an oxidation reaction in order to obtain aromatic aldehyde.

Process for preparing mandelic aromatic compounds and aromatic aldehyde compounds

Process for the synthesis of the compound of formula (I): Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.

Process for the synthesis of 3,4-dimethoxybicyclo[4.2.0]OCTA-1,3,5-triene-7-carbonitrile, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid

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Camblanes et Meynac, France

Mathieu Pucheault