Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Ecole Superieure De Physique Et De Chimie Industrielles De La Ville De Paris

Supersonic Imagine

Université Paris Diderot-paris 7

Sorbonne Université

Universite Paris Cité

Université Pierre Et Marie Curie (paris 6)

Inserm (institut National De La Sante Et De La Recherche Medicale)

Columbia University

Assistance Publique-hopitaux De Paris

Centre National De La Recherche Scientifique-cnrs

Université Pierre Et Marie Curie

Institut National De Recherche En Informatique Et En Automatique

Université Paris Diderot

Mathieu Pernot

Mickaël Tanter

Thomas Deffieux

Mickael Tanter

Jean-Luc Gennisson

Mathias Fink

Clément Papadacci

Mathieu Couade

Elisa E Konofagou

Jeremy Bercoff

Jean-François Aubry

Yves Martin

Zsolt Lenkei

Michael Vion

Ralph Sinkus

Bertrand Tavitian

Claude Cohen-Bacrie

David Savery

Gabriel Montaldo

Emmanuel Messas

Jérémy Bercoff

Bruno-Félix Osmanski

Daniel Suarez

Hugues Favre

Dominique Chapelle

Philippe Moireau

Oscar Demeulenaere

Jean Provost

Anikitos Garofalakis

Thomas Viel

Justine Robin

Ivan Cohen

Olivier Villemain

Guillaume Goudot

François Varray

Claude Cohen-bacrie

Jean-Francois Aubry

While 3D ultrasound imaging is becoming a powerful tool in medical field, the main drawback is the difficulty to image large 3D volume, mainly related to the dimensions of the 2D array of transducers. In order to not lose in spatial resolution, it is necessary to use an array of transducers, wherein the size of the transducers does not exceed the wavelength of the ultrasound wave. Such requirement leads to dimensions of array for imaging large 3D volume which are not reachable or at too high cost with the current technology. The present disclosure overcomes the above technology limitation by using greater transducers, and where each transducer has a reception surface with a curved shape or is fitted with an acoustic lens. Such configuration of transducers leads to 2D array of transducers suitable for imaging large 3D volume, as a brain or a heart, with high resolution and high sensitivity.

Divergent lens array

The present invention relates to the field of ultrasounds and imagining of the coronary blood flow of the heart. Patients with coronary microvascular dysfunction (CMD) have poor prognostic with significantly higher rates of cardiovascular events, including hospitalization for heart failure, sudden cardiac death, and myocardial infarction (MI). Despite the urgent clinical need, there are no non-ionizing and non-invasive techniques available in clinic to directly visualize the coronary microvasculature and assess the local coronary microvascular system. Flow imaging remains a difficult task to perform in the heart because of the fast movements of this organ. In order to overcome the limitations of actual imaging methods for the coronary blood flow, the inventors proposed an ultrasound ultrafast imaging method that automatically detect the time periods in which the myocardium velocity is low and estimate the coronary flow velocity and the tissue velocity from the same data acquisition.

3-D ultrasound coronarography, a non-ionizing and non-invasive technology for multi-scale anatomical and functional imaging of coronary circulation

A cardiac device comprises a transmitter () arranged to transmit at least one wave, a probe () arranged to measure a shear wave caused by a wave coming from the transmitter (), a detector () arranged to detect a systole phase in an electrocardiographic signal, and an estimator () arranged to determine, during at least one cardiac cycle, the propagation speed of a plurality of shear waves caused by the transmission of waves in several directions towards the heart of a patient, to determine using the detector () that which has a maximum propagation speed during the systole phase, and to derive an active cardiac stress response therefrom ().

Cardiac device

The invention relates to a method for determining at least one property of an object, the method comprising a step of: a) obtaining first data relative to the object by an ultrasound imaging technique imaging the object at a frame rate superior to 300 Hz, characterized in that the method further comprises a step of: b) obtaining second data relative to the object by imaging the object with at least one of a X-ray and a γ-ray, and c) determining the at least one property of the object based on the first data and the second data.

Method for determining a property of an object and associated device

Because of the increase of the obesity related diseases, it is desirable to be able to detect a fatty liver and quantify the content in fat for the fatty liver. Known methods are biopsy and magnetic resonance imaging. However, biopsy is an invasive method and magnetic resonance imaging is a complicated method to carry out. The inventors propose a new ultrasonic method, which is more compliant with a regular control of the content in fat for the fatty liver for a subject. This method notably relies on a smart exploitation of the coherence properties of ultrasound pulses applied to the liver. This method has already been validated on sane subjects as providing accurate measurements, notably for fat content.

Method for measuring the speed of sound in liver with a specific probe and associated methods and devices

The invention concerns a multi-sensor brain detecting apparatus, the detecting apparatus being adapted to obtain two different physical values of a brain of a subject, the detecting apparatus comprising:

Multi-sensor brain detecting apparatus

A method for mapping fibrous media by propagation of ultrasound from a set transducers, wherein: a number of unfocused incident ultrasonic waves having different wavefronts are emitted; the signals reverberated by the medium toward each transducer are captured; coherent signals respectively corresponding, for each transducer, to contributions coming from different fictitious focal points in the medium are determined; and then the orientation of the fibers is determined by comparing a spatial coherence between said coherent signals, in a plurality of directions.

Method and device for mapping fibrous media

An apparatus for treating vascular thrombosis with ultrasound, includes a therapeutic ultrasonic transducer, suitable for generating focused ultrasonic waves that propagate along an emission axis; an imaging ultrasonic transducer associated with the therapeutic transducer; a means for moving the focal spot of the therapeutic ultrasonic transducer along the emission axis with respect to the imaging transducer; a motorized mechanical system for translating the transducers along at least a first axis parallel to the emission axis and a second axis perpendicular to the first; and an electronic control system for driving the motorized mechanical system and the means for moving the focal spot of the therapeutic transducer.

Apparatus for treating vascular thrombosis by ultrasounds

The present invention aims at improving the Doppler imaging of a biological sample comprising blood. For this, it is proposed a method for imaging a biological sample (), the sample () comprising blood () comprising diffusors and solid tissue (), the method comprising obtaining observation, each observation being characterized by a different point spread function associating a signal to each location of the region of interest, the signal comprising a first contribution representative of the diffusors of blood vessels within the location, a second contribution representative of the tissue diffusors and a third contribution representative of blood signal associated to blood diffusors outside of the location, and estimating, for each location, the blood flow by using a statistical analysis.

Method for imaging a sample with blood and associated devices

An ultrasonic processing apparatus is provided. The ultrasonic processing apparatus comprises an ultrasonic therapy transducer (ATA) adapted to generate focused ultrasonic waves; an ultrasonic imaging transducer (UID) connected to the ultrasonic therapy transducer; and an electronic system configured to control the ultrasonic therapy transducer so as to emit a pulse train of ultrasonic waves generating a cloud of cavitation bubbles (BC); control the ultrasonic imaging transducer so as to acquire at least one image of the region to be processed; acquire a plurality of echo signals of ultrasonic wave pulses emitted by the ultrasonic therapy transducer captured by the ultrasonic imaging transducer; process the plurality of echo signals so as to reconstruct an image of the cloud of cavitation bubbles; and display said image of the cloud of cavitation bubbles superposed on said image of the region to be processed. The processing includes spatio-temporal filtering.

Ultrasonic processing apparatus comprising means for imaging cavitation bubbles

An ultrasound imaging and therapy device includes an array of concentric annular ultrasound transducers, and an ultrasound imaging device situated inside an innermost transducer of the plurality of concentric annular ultrasound transducers, wherein it further comprises a mechanical linkage allowing a tilting movement of the array of concentric annular ultrasound transducers with respect to the ultrasound imaging device and in that the ultrasound imaging device protrudes in an axial direction from the array of concentric annular ultrasound transducers; whereby the ultrasound imaging device can be kept stationary and in direct or indirect contact with a patient's skin while the array of concentric annular ultrasound transducers is tilted so as to move a focal point of ultrasound waves generated by the concentric annular ultrasound transducers within an imaging region of the ultrasound imaging device.

Ultrasound imaging and therapy device

The invention relates to a method for obtaining a numerical model, the numerical model associating at least one objective measurement to a subjective sensation, the method comprising the steps of: a) imaging the at least one area of the brain by using unfocused waves produced by a transcranial ultrasound probe (), to obtain at least one acquired image of the activity of the area, b) evaluating a physical quantity representative of the activity of the at least one area based on the acquired images, to obtain at least one objective measurement, c) obtaining from the subject at least one numerical value representative of a subjective sensation, and d) determining the numerical model by using the obtained objective measurement and the obtained numerical value.

Method for obtaining a numerical model associating an objective measurement to a subjective sensation using ultrasound imaging technique and associated device

A method for characterizing an anisotropic soft medium (C) including fibers and having an outer surface (), by observing in different propagation directions, the propagation of a divergent shear wave from a central area () in the anisotropic soft medium. A propagation parameter of the shear wave is inferred therefrom in each of the propagation directions, and then a direction of the fibers of the anisotropic soft medium, a rheological elasticity parameter are determined in a direction perpendicular to the fibers and a rheological elasticity parameter in the direction of the fibers.

Ultrasonic method and device for characterising weak anisotropic media, and ultrasonic probe assembly for such a characterisation device

The invention concerns a detecting apparatus () comprising:&#x2014;at least two sensors (), with at least one sensor () being an ultrasound transducer adapted to produce ultrasound waves, and&#x2014;a positioning device () defining several compartments (), each compartment () being adapted to hold a sensor () and each compartment () being located at predetermined location, the positioning device () comprising a holder adapted to be fixed on the skull of a subject, the positioning device () being adapted to be maintained on the head of the subject using the holder.

Detecting apparatus and associated kit and method

In order to obtain a predetermined ultrasonic wave field in a homogeneous internal part of a medium masked by an aberrating barrier, an ultrasonic lens is interposed between the emitting ultrasonic probe and the aberrating barrier. The ultrasonic lens is calculated by using a model of the medium comprising a mapping of ultrasonic wave propagation properties obtained from actual imaging of the medium such that when the ultrasound probe sends a predetermined ultrasonic wave, said predetermined wave generates the predetermined objective ultrasonic wave field in the medium.

Insonification method for obtaining a predetermined field of ultrasonic waves and production method for making an ultrasonic lens for these purposes

Growing community of inventors

Paris, France

Mathieu Pernot