Centre National De La Recherche Scientifique

National Institute for Agricultural Research

Mathieu Galibert

Vincent Aucagne

Agnes Delmas

Massimiliano Beltramo

Alain Caraty

A KISS1R agonist peptide compound capable of inducing ovulation in a female mammal is provided. The compound is a pseudopeptide having the C-terminal sequence: -Xaa&#x3a8;[Tz]Xaa2-Xaa3-Xaa4-NH(SEQ ID NO: 3), where &#x3a8;[Tz] represents a 1,4-disubstituted 1,2,3-triazole group replacing the peptide bond between the Xaa1 residue and the Xaa2 residue, Xaa1 is Gly or Ala, Xaa2 is Leu or an aliphatic &#x3b1;-aminoacyl analog residue, Xaa3 is Arg, Arg(Me) or a positively charged &#x3b1;-aminoacyl analog residue, and Xaa4 is Tyr, Phe, Trp or an &#x3b1;-aminoacyl analog residue such as aryl alanine; or an analog of the pseudopeptide in which the amide peptide bond between Xaa2 and Xaa3 and/or between Xaa3 and Xaa4 is replaced with an isosteric bond, or a salt thereof.

Growing community of inventors

Orleans, France

Mathieu Galibert