Basf Se Corporation

Basf Se (reitstÖtter, Kinzebach & Partner)

Mathias Schelwies

Johann-Peter Melder

Joaquim Henrique Teles

Rocco Paciello

Thomas Schaub

Oliver Bey

Gunnar Heydrich

Martin Merger

Martin Haubner

Georg Seeber

Boris Buschhaus

Marion Kristina Brinks

Stephanie Renz

Wolfgang Siegel

Peter Zehner

Günter Wegner

Ralf Pelzer

Roland Goetz

Michael Breuer

Alexander Panchenko

Andreas Keller

Dominic Riedel

Christopher Koradin

Florian Vogt

Florian Garlichs

Gerd-Dieter Tebben

Guenter Wegner

Jonas Schwaben

Melanie Weingarten

Rene Backes

Gerd Tebben

Benoit Blank

Martine Dehn

Monika Charrak

Stefan Ruedenauer

Michael Acker

A Stephen K Hashmi

Marion Kristina Da Silva

Frauke Thrun

Heinz Eckhardt

Aviel Anaby

Viktoriia Zubar

Rocco Pacielo

Marion Da Silva

The present invention relates to a method for isomerizing a 3-(Z)-unsaturated carboxylic acid of the formula 1-Z or a salt thereof, wherein Ris C-C-alkyl, C-C-alkenyl having 1, 2, 3 or more than 3 C—C double bonds, unsubstituted or substituted C-C-cycloalkyl, or unsubstituted or substituted aryl; Ris hydrogen or has one of the definitions specified for R; with the proviso that Rhas a higher priority than Rin accordance with IUPAC; to give a 3-(E)-unsaturated carboxylic acid of the formula I-E or a salt thereof, wherein the isomerization of the compound of the formula 1-Z is effected in the presence of an anhydride of an organic acid and a base or in the presence of a ketene of formula CRRC(0), wherein Rand Rare as defined in the claims and in the specification and a base. In particular, the present invention relates to a method for preparing compositions with increased content of (3E,7E)-homofarnesylic acid starting from compositions comprising (3Z,7E)- and (3E,7E)-homofarnesylic acid.

Method for the isomerization of a 3-(Z)-unsaturated carboxylic acid to the 3-(E)-isomer

A reactor for performing a gas/liquid biphasic high-pressure reaction with a foaming medium, comprising an interior formed by a cylindrical, vertically oriented elongate shell, a bottom and a cap, wherein the interior is divided by internals into a backmixed zone and a zone of limited backmixing, wherein the backmixed zone and the zone of limited backmixing are consecutively traversable by the reaction mixture, wherein the backmixed zone comprises means for introducing gas and liquid and a gas outlet and also comprises at least one mixing apparatus selected from a stirrer, a jet nozzle and means for injecting the gas, and the zone of limited backmixing comprises a reaction product outlet, a first cylindrical internal element which in the interior extends in the longitudinal direction of the reactor and which delimits the zone of limited backmixing from the backmixed zone, backmixing-preventing second internal elements in the form of random packings, structured packings or liquid-permeable trays arranged in the zone of limited backmixing and a riser tube whose lower end is arranged within the backmixed zone and whose upper end opens into the zone of limited backmixing so that liquid from the backmixed zone can ascend into the zone of limited backmixing via the riser tube, wherein flow into the zone of limited backmixing enters from below. The reactor is configured such that the high-pressure reaction space is optimally utilized and contamination of workup steps or subsequent reactions arranged downstream of the high-pressure reaction with foam is substantially avoided. The invention further relates to a process for performing a continuous gas/liquid biphasic high-pressure reaction in the reactor.

Reactor for carrying out a gas-liquid two-phase high-pressure reaction with a foaming medium

A process for performing a continuous gas/liquid biphasic high-pressure reaction, wherein a gas and a liquid are introduced into a backmixed zone of a reactor and in the backmixed zone the gas is dispersed in the liquid by stirring, injection of gas and/or a liquid jet, a reaction mixture consecutively traverses the backmixed zone and a zone of limited backmixing, and a liquid reaction product is withdrawn at a reaction product outlet of the zone of limited backmixing, wherein the reactor comprises: an interior formed by a cylindrical vertically oriented elongate shell, a bottom and a cap, wherein the interior is divided by means of internals into the backmixed zone, the zone of limited backmixing and a cavity, a first cylindrical internal element which in the interior extends in the longitudinal direction of the reactor and which delimits the zone of limited backmixing from the backmixed zone, backmixing-preventing second internal elements in the form of random packings, structured packings or liquid-permeable trays arranged in the zone of limited backmixing and a third internal element which in the interior extends in the longitudinal direction of the reactor and is open at the bottom, wherein the third internal element forms the cavity in which gas bubbles collect and do not escape upwards, thus preventing the volume of the cavity from being occupied by liquid and reducing the reaction volume. The reaction volume of the reactor used in the process can be reversibly reduced in simple fashion. The invention further relates to a process for adapting the reaction volume of a reactor suitable for performing a gas/liquid biphasic high-pressure reaction having an outlet for a liquid reaction product in which an internal element is arranged so as to form a cavity open at the bottom in which gas bubbles collect and do not escape upwards, thus preventing the volume of the cavity from being occupied by liquid and reducing the reaction volume.

Method for carrying out a gas/fluid two-phase high-pressure reaction

Method for hydrogenating an ester with molecular hydrogen to the corresponding alcohols in the presence of a ruthenium complex (I), wherein said complex comprises a tridentate ligand L of the general formula (II) n and m are each independently 0 or 1, and the solid-dashed double lines represent a single or double bond, with the proviso that in the case of n=1 both solid-dashed double lines represent a single bond and m is 1, and in the case of n=0 one solid-dashed double line represents a single bond and the other solid-dashed double line represents a double bond, wherein in the case of a double bond on the side facing the phenyl ring m=1, in the case of a double bond on the side facing the pyridyl ring m=0, or both solid-dashed double lines represent a single bond and m is 1.

Hydrogenation of esters to alcohols in the presence of a Ru-PNN complex

A reactor for performing a reaction between two immiscible fluids of different density, comprising an interior formed by a cylindrical, vertically oriented elongate shell, a bottom and a cap, wherein the interior is divided by internals into a backmixed zone, a zone of limited backmixing preferably arranged below the backmixed zone and a plug-flow zone which are at least consecutively traversable by one of the fluids, wherein the backmixed zone comprises at least one inlet and the plug-flow zone comprises an outlet and the backmixed zone comprises at least one mixing apparatus selected from a stirrer, a jet nozzle and means for injecting the fluid of lower density, a first cylindrical internal element which in the interior extends in the longitudinal direction of the reactor, which delimits the zone of limited backmixing from the plug-flow zone and which comprises a first passage to the backmixed zone and a second passage to the plug-flow zone, a second internal element which delimits the backmixed zone from the plug-flow zone such that there is no direct fluid connection between the backmixed zone and the plug-flow zone, and backmixing-preventing third internal elements in the form of random packings, structured packings or liquid-permeable trays arranged in the zone of limited backmixing. The reactor allows an optimal residence time distribution in the reaction of the two immiscible fluids of different density. The invention further relates to a process for performing a continuous reaction in the reactor.

Reactor for carrying out a reaction between two non-miscible fluids of different densities

The present invention relates to the use of a transition metal catalyst TMC1, which comprises a transition metal M selected from metals of groups 7, 8, 9 and 10 of the periodic table of elements according to IUPAC and a tetradentate ligand of formula I wherein Rare identical or different and are each an organic radical having from 1 to 40 carbon atoms, and Rare identical or different and are each an organic radical having from 1 to 40 carbon atoms, as catalyst in processes for formation of compounds comprising at least one carboxylic acid ester functional group &#x2014;O&#x2014;C(&#x2550;O)&#x2014; starting from at least one primary alcohol and/or hydrogenation of compounds comprising at least one carboxylic acid ester functional group &#x2014;O&#x2014;C(&#x2550;O)&#x2014;. The present invention further relates to a process for hydrogenation of a compound comprising at least one carboxylic acid ester functional group &#x2014;O&#x2014;C(&#x2550;O)&#x2014;, to a process for the formation of a compound comprising at least one carboxylic acid ester functional group &#x2014;O&#x2014;C(&#x2550;O)&#x2014; by dehydrogenase coupling of at least one primary alcohol with a second alcoholic OH-group, to a transition metal complex comprising the tetradentate ligand of formula I and to a process for preparing said transition metal complex. 

Use of a transition metal catalyst comprising a tetradentate ligand for hydrogenation of esters and/or formation of esters, a process for hydrogenation of esters, a process for formation of esters and a transition metal complex comprising said tetradentate ligand

The present invention relates to a process for the preparation of an optically active carbonyl compound by asymmetric hydrogenation of a prochiral &#x3b1;,&#x3b2;-unsaturated carbonyl compound with hydrogen in the presence of at least one optically active transition metal catalyst that is soluble in the reaction mixture and which has rhodium as catalytically active transition metal and a chiral, bidentate bisphosphine ligand, wherein the reaction mixture during the hydrogenation of the prochiral &#x3b1;,&#x3b2;-unsaturated carbonyl compound additionally comprises at least one compound of the general formula (I):

Method for synthesizing optically active carbonyl compounds

The present invention relates to a process for carbonylating allyl alcohols at low temperature, low pressure and/or low catalyst loading. In an alternative embodiment, an acylation product of the allyl alcohol is used for the carbonylation. The present invention likewise relates to the preparation of conversion products of these carbonylation products and specifically of (&#x2212;)-ambrox.

Process for the preparation of unsaturated carboxylic acids by carbonylation of allyl alcohols and their acylation products

The invention provides an improved method of isolating the 3-(E)-isomer of an unsaturated carboxylic acid from a mixture of corresponding (E/Z)isomers. More particularly, the present invention relates to an improved method for the biocatalytic preparation of (3E,7E)-homofarnesylic acid; as well as a novel biocatalytic method for the improved preparation of homofarnesol, in particular of (3E,7E)-homofarnesol and homofarnesol preparations having an increased content of (3E,7E)-homofarnesol. The present invention also relates to methods of preparing(&#x2212;)-ambroxby applying (3E,7E)-homofarnesylic acid or (3E,7E)-homofarnesol as obtained according to the invention as starting material.

Method for the preparation of (3E,7E)-homofarnesic acid or (3E,7E)-homofarnesic acid ester

The present invention relates to a process for the preparation of an optically active carbonyl compound by asymmetric hydrogenation of a prochiral &#x3b1;,&#x3b2;-unsaturated carbonyl compound with hydrogen in the presence of at least one optically active transition metal catalyst that is soluble in the reaction mixture and which has rhodium as catalytically active transition metal and a chiral, bidentate bisphosphine ligand, wherein the reaction mixture during the hydrogenation of the prochiral &#x3b1;,&#x3b2;-unsaturated carbonyl compound additionally comprises at least one compound of the general formula (I): 

The present invention relates to a process for preparing farnesyl acetone.

Method of producing farnesyl acetone

The present invention relates to a process for the preparation of an optically active carbonyl compound by asymmetric hydrogenation of a prochiral &#x3b1;,&#x3b2;-unsaturated carbonyl compound with hydrogen in the presence of at least one optically active transition metal catalyst that is soluble in the reaction mixture and which has rhodium as catalytically active transition metal and a chiral, bidentate bisphosphine ligand, wherein the reaction mixture during the hydrogenation of the prochiral &#x3b1;,&#x3b2;-unsaturated carbonyl compound additionally comprises at least one compound of the general formula (I): in which

Process for preparing primary amines which have at least one functional group of the formula (&#x2014;CH&#x2014;NH) and at least one further primary amino group by alcohol amination of starting materials having at least one functional group of the formula (&#x2014;CH&#x2014;OH) and at least one further functional group (&#x2014;X), where (&#x2014;X) is selected from among hydroxyl groups and primary amino groups, by means of ammonia with elimination of water, wherein the reaction is carried out homogeneously catalyzed in the presence of at least one complex catalyst comprising at least one element selected from groups 8, 9 and 10 of the Periodic Table and also at least one donor ligand.

Process for preparing di-, tri- and polyamines by homogeneously catalyzed alcohol amination

Process for preparing alkanolamines which have a primary amino group (&#x2014;NH) and a hydroxyl group (&#x2014;OH) by alcohol amination of diols having two hydroxyl groups (&#x2014;OH) by means of ammonia with elimination of water, wherein the reaction is carried out homogeneously catalyzed in the presence of at least one complex catalyst comprising at least one element selected from groups 8, 9 and 10 of the Periodic Table and also at least one donor ligand.

Process for preparing alkanolamines by homogeneously catalyzed alcohol amination

Growing community of inventors

Heidelberg, Germany

Mathias Schelwies