The Johns Hopkins University

Mathias Oelke

Jonathan Schneck

Karlo Perica

Joan Glick Bieler

This disclosure provides nano-scale Artificial Antigen Presenting Cells (aAPC), which deliver stimulatory signals to lymphocytes, including T-helper lymphocytes, for use as a powerful tool for immunotherapy.

Nanoscale artificial antigen presenting cells

Antigen-specific T cells, including nave T cells, and including rare precursor cells are enriched and expanded in culture. Enrichment and expansion provides a platform for more effective immunotherapy by adoptive transfer, as well as platforms for personalizing immunotherapy by determining T cell reactivity with a library of candidate peptide antigens.

Reagents and methods for identifying, enriching, and/or expanding antigen-specific T cells

This disclosure provides nano-scale Artificial Antigen Presenting Cells (aAPC), which deliver stimulatory signals to lymphocytes, including cytotoxic lymphocytes, for use as a powerful tool for immunotherapy.

Growing community of inventors

Parkville, MD, United States of America

Mathias Oelke